A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3‐Disubstituted Indolines
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DOI: 10.1002/ajoc.201900289
Abstract: A divergent and enantioselective procedure for synthesis of 2,3-disubstituted indolines was developed through Brønsted acid/palladium-complex promoted condensation/reductive alkylation/ hydrogenation cascade reactions from simple amino ketones and aldehydes in one operation. Five Brønsted acid-promoted steps and… read more here.
Keywords: disubstituted indolines; chiral disubstituted; synthesis; nsted acid ... See more keywords
Iron-Catalyzed Regiospecific Intermolecular Radical Cyclization of Anilines: Strategy for Assembly of 2,2-Disubstituted Indolines.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00176
Abstract: The first regiospecific catalytic intermolecular assembly of 2,2-disubstituted indolines has been developed. This protocol is based on a ligand and directing group free, iron-catalyzed radical [3 + 2] process, allowing efficient coupling of different N-sulfonylanilines… read more here.
Keywords: intermolecular radical; regiospecific intermolecular; iron catalyzed; assembly disubstituted ... See more keywords