Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines.
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DOI: 10.1021/acscatal.0c00211
Abstract: The development of a general method utilizing a hydroxymethyl directing group for asymmetric hydrogenation of 1,3-disubstituted isoquinolines to provide chiral 1,2,3,4-tetrahydroisoquinolines is reported. The reaction, which utilizes [Ir(cod)Cl]2 and a commercially available chiral xyliphos ligand,… read more here.
Keywords: hydrogenation; iridium catalyzed; catalyzed enantioselective; enantioselective diastereoselective ... See more keywords
Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06729j
Abstract: The development of the first asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines is reported. Utilizing [Ir(cod)Cl]2 and a commercially available chiral Josiphos ligand, a variety of differentially substituted isoquinolines are hydrogenated to produce enantioenriched trans-tetrahydroisoquinolines in… read more here.
Keywords: hydrogenation disubstituted; hydrogenation; disubstituted isoquinolines; asymmetric trans ... See more keywords