Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams.
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DOI: 10.1039/c7cc01058c
Abstract: The direct enantioselective vinylogous Michael addition of unsaturated γ-monosubstituted γ-lactams was realized by using chiral phase-transfer catalysis as a means to give enantioenriched γ,γ-disubstituted γ-lactams. read more here.
Keywords: catalyzed asymmetric; transfer catalyzed; phase transfer; synthesis unsaturated ... See more keywords
Divergent and Diastereoselective Synthesis of α-Monosubstituted and trans-α,β-Disubstituted γ-Lactams from (S)-N,N-Dibenzyl-α-amino Aldehydes via Henry and Michael Reactions
Sign Up to like & getrecommendations! Published in 2020 at "Synthesis"
DOI: 10.1055/s-0040-1706423
Abstract: γ-Monosubstituted and trans-α,β-disubstituted γ-lactams were diastereoselectively synthesized from common intermediates (S)-N,N-dibenzylated aldehydes derived from natural l -(α)-amino acids, employing a divergent approach. The key features of the routes include diastereoselective Henry and Michael reactions that… read more here.
Keywords: amino; michael reactions; trans disubstituted; henry michael ... See more keywords