Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis.
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DOI: 10.1021/acs.jmedchem.8b01635
Abstract: Multiple sclerosis (MS) is a disease of the autoimmune-mediated disorder in the central nervous system, for which no effective therapeutic agent is currently available. The regulation of macrophage polarization toward M2 is a general benefit… read more here.
Keywords: macrophage polarization; polarization; phenotypic screening; multiple sclerosis ... See more keywords
2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora
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DOI: 10.1055/a-1903-2663
Abstract: Abstract Three new alkaloids, hipporidine A ( 1 ), hipporidine B ( 2 ), and (−)-lobeline N -oxide ( 3 ), were discovered from the whole plant of Hippobroma longiflora together with five known compounds… read more here.
Keywords: disubstituted piperidine; neuroprotective activity; hippobroma longiflora; alkaloids neuroprotective ... See more keywords
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
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DOI: 10.3390/molecules25020299
Abstract: In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting… read more here.
Keywords: synthesis antimalarial; piperidine derivatives; antimalarial activity; disubstituted piperidine ... See more keywords