High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11
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DOI: 10.1128/msphere.00075-22
Abstract: Pathogenic fungi represent a serious but underacknowledged threat to human health. The treatment and management of these infections relies heavily on the use of azole antifungals, a class of molecules that contain a five-membered nitrogen-containing… read more here.
Keywords: antifungal activity; disubstituted pyridine; novel antifungal; chemical ... See more keywords
2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli
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DOI: 10.3389/fphar.2022.1004632
Abstract: It was recently reported that 4-substituted picolinohydrazonamides carrying hydrophilic cyclic amines, such as morpholine and pyrrolidine, at the end of their thiosemicarbazide chain have potent antimycobacterial activity in vitro at concentrations below 1 μg/ml. Here,… read more here.
Keywords: disubstituted pyridine; forming tubercle; pyridine derivatives; biofilm forming ... See more keywords