Stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via a Beckmann rearrangement facilitated by diphenyl phosphorazidate
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.04.014
Abstract: Abstract A novel method for the stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via the Beckmann rearrangement was developed using diphenyl phosphorazidate (DPPA) as both the oxime activator and azide source. Various ketoximes were transformed… read more here.
Keywords: tetrazoles ketoximes; disubstituted tetrazoles; stereospecific synthesis; synthesis disubstituted ... See more keywords
Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles
Sign Up to like & getrecommendations! Published in 2017 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.13.256
Abstract: Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained. Herein, we… read more here.
Keywords: disubstituted tetrazoles; ugi azide; acylhydrazines bearing; hydrazino ugi ... See more keywords