Effect of introducing a disulfide bridge on the thermostability of microbial transglutaminase from Streptomyces mobaraensis.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11200-6
Abstract: Microbial transglutaminase (MTG) has been used extensively in academic research and the food industry through cross-linking or posttranslational modification of proteins. In our previous paper, the activity-increased MTG mutants were obtained by means of rational… read more here.
Keywords: microbial transglutaminase; bridge; disulfide bridge; mtg ... See more keywords
Disulfide bridge formation to increase thermostability of DFPase enzyme: A computational study
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.09.005
Abstract: Organophosphate compounds bioremediation by use of organophosphorus degradation enzymes such as DFPase is a developing interest in industry and medicine. The most important problem with the bio-catalytic enzymes is their instability on high temperatures. This… read more here.
Keywords: thermostability; bridge formation; dfpase enzyme; disulfide bridge ... See more keywords
The essential cysteines in the CIPC motif of the thioredoxin-like Trypanosoma brucei MICOS subunit TbMic20 do not form an intramolecular disulfide bridge in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2022.111463
Abstract: The mitochondrial protein import machinery of trypanosomatids is highly divergent from that of the well-studied models such as baker's yeast. A notable example is that the central catalyst of the mitochondrial intermembrane space import and… read more here.
Keywords: disulfide; form; micos; intramolecular disulfide ... See more keywords
Disulfide-bridge dimeric porphyrin and their reference compounds for glutathione-based specific tumor-activation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s1088424617500961
Abstract: The tumor micro-environment is rich in glutathione. To exploit this feature for tumor-activatable porphyrin-based photosensitizers, a dimeric disulfide-bridged porphyrin has been designed and prepared, together with two reference derivatives, a non-cleavable dimer and a monomer.… read more here.
Keywords: reference; porphyrin; disulfide bridge; glutathione ... See more keywords
Enhancement of Pharmaceutical Urate Oxidase Thermostability by Rational Design of De Novo Disulfide Bridge
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2020.2662
Abstract: Background and Purpose: As a therapeutic enzyme, urate oxidase is utilized in the reduction of uric acid in various conditions such as gout or tumor syndrome lysis. However, even bearing kinetical advantage over other counterparts,… read more here.
Keywords: novo disulfide; rational design; oxidase; disulfide bridge ... See more keywords