Cis/trans isomerization of proline peptide bonds in the backbone of cyclic disulfide‐bridged peptides
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DOI: 10.1002/pep2.24088
Abstract: Peptides are of interest as potential therapeutic agents, including cyclic disulfide‐bridged peptides because of their limited conformational flexibility and enhanced stability toward proteolysis. To further constrain the flexibility of the peptide backbone, the disulfide‐bridged rings… read more here.
Keywords: cys; peptide bonds; proline peptide; cis trans ... See more keywords
BSA modified, disulfide-bridged mesoporous silica with low biotoxicity for dual-responsive drug delivery
Sign Up to like & getrecommendations! Published in 2019 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2018.12.001
Abstract: Abstract Siliceous materials based intelligent drug delivery systems (DDS) have attracted numerous attentions. Unfortunately, their intrinsic biologic inertia and non-degradability are critical issues need to be addressed because it hampers further clinical translation application. Herein,… read more here.
Keywords: mesoporous silica; bsa modified; drug; bridged mesoporous ... See more keywords
Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00364
Abstract: An enantioselective vinylcyclopropane ring-opening/cycloaddition cascade is described. The active thiyl radical catalysts are generated in situ via UV light-promoted homolysis of cystine-based dimers. Amide-functionalization of the peptide at the 4-proline position is essential for effective… read more here.
Keywords: mediate enantioselective; thiyl radical; enantioselective cycloadditions; disulfide bridged ... See more keywords
Disulfide Bridged Nanoparticles of Thiolated Sodium Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation
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DOI: 10.1021/acsomega.3c00400
Abstract: Most biopharmaceutics classification system (BCS) class IV drugs have limited oral bioavailability due to poor solubility and poorer permeability. This work aims to investigate the possibility of utilizing disulfide bridged nanoparticles to improve BCS IV… read more here.
Keywords: bridged nanoparticles; sodium alginate; ptl; thiolated sodium ... See more keywords
Biodegradable Materials with Disulfide-Bridged-Framework Confine Photosensitizers for Enhanced Photo-Immunotherapy [Corrigendum]
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DOI: 10.2147/ijn.s356643
Abstract: [This corrects the article DOI: 10.2147/IJN.S344679.]. read more here.
Keywords: biodegradable materials; bridged framework; framework confine; confine photosensitizers ... See more keywords