Solid-Phase Synthesis and Antibacterial Activity of an Artificial Cyclic Peptide Containing Two Disulfide Bridges
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9757-y
Abstract: Synthesis of artificial antibacterial peptides containing multiple disulfide bridges is of particular interest in bioorganic chemistry. In this paper, a straightforward on-resin synthesis of a cyclic peptide containing two disulfide bridges by orthogonal protection approach… read more here.
Keywords: disulfide bridges; cyclic peptide; peptide containing; containing two ... See more keywords
Key Role of Disulfide Bridges in the Antimicrobial Activity of Beta-Defensin from Olive Flounder
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09837-z
Abstract: Proteins that contain multiple disulfide bonds (SS bonds) expressed in Escherichia coli are usually problematic. This study reports the successful recombinant expression of the antimicrobial peptide β-defensin isolated from olive flounder in E. coli .… read more here.
Keywords: defensin; olive flounder; beta defensin; spectroscopy ... See more keywords
Online Electrochemical Reduction of Both Inter- and Intramolecular Disulfide Bridges in Immunoglobulins.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04261
Abstract: Electrochemical reduction of intermolecular disulfide bridges has previously been demonstrated in immunoglobulins but failed to achieve reduction of intramolecular bonds. We now report an improved method that achieves the full reduction of both intermolecular and… read more here.
Keywords: electrochemical reduction; intramolecular disulfide; online electrochemical; reduction ... See more keywords
Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20181073
Abstract: Coiled-coils are ubiquitous protein–protein interaction motifs found in many eukaryotic proteins. The elongated, flexible and often irregular nature of coiled-coils together with their tendency to form fibrous arrangements in crystals imposes challenges on solving the… read more here.
Keywords: sulfur sad; coiled coils; sad phasing; combinatorial use ... See more keywords