Motif-Directed Oxidative Folding to Design and Discover Multicyclic Peptides for Protein Recognition.
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DOI: 10.1021/acs.accounts.5c00060
Abstract: ConspectusMulticyclic peptides that are constrained through covalent cross-linkers can usually maintain stable three-dimensional (3D) structures without the necessity of incorporating noncovalently interacting cores. This configuration allows for a greater utilization of residues for functional purposes… read more here.
Keywords: oxidative folding; multicyclic peptides; disulfide directing; sequence ... See more keywords