Fast-Forming Dissolvable Redox-Responsive Hydrogels: Exploiting the Orthogonality of Thiol–Maleimide and Thiol–Disulfide Exchange Chemistry
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00209
Abstract: Fast-forming yet easily dissolvable hydrogels (HGs) have potential applications in wound healing, burn incidences, and delivery of therapeutic agents. Herein, a combination of a thiol–maleimide conjugation and thiol–disulfide exchange reaction is employed to fabricate fast-forming… read more here.
Keywords: thiol; thiol maleimide; chemistry; fast forming ... See more keywords
Visible light triggered controlled formation of rapidly self-healing hydrogels based on thiol-disulfide exchange.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d1sm01698a
Abstract: The properties of stimuli-responsive hydrogels can be tailored under various external stimuli, but it is difficult to realize the customized adjustment of hydrogel properties since the crosslinking degree in the gelation process is intractable. Here,… read more here.
Keywords: light triggered; thiol disulfide; visible light; disulfide exchange ... See more keywords
Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.01471-24
Abstract: ABSTRACT Disulfide exchange is underexplored as a mechanism influencing HIV-1 entry. Prior studies demonstrated that redox enzyme inhibition can prevent HIV-1 infection but with limited mechanistic explanation. We hypothesize that ligand-driven rearrangement (“conformational activation”) enables… read more here.
Keywords: hiv; conformational activation; exchange; entry ... See more keywords