l-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI)
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9817-7
Abstract: The unfolded protein response (UPR) is a highly evolutionarily conserved response to endoplasmic reticulum (ER) stress, which functions to return cells to homeostasis or send them into apoptosis, depending on the degree of cellular damage.… read more here.
Keywords: protein; disulfide isomerase; serine; protein disulfide ... See more keywords
Identification of amphioxus protein disulfide isomerase as both an enzyme and an immunocompotent factor.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104238
Abstract: Previous studies have shown that protein disulfide isomerase (PDI), a member of the thioredoxin (TRX) superfamily, are broadly associated in immune responses in a variety of animals. However, it remains largely unknown about the direct… read more here.
Keywords: immunocompotent factor; disulfide isomerase; protein disulfide; isomerase ... See more keywords
Protein Disulfide Isomerase increases Nox1 activation through EGFR signaling in hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.302
Abstract: We have previously shown that expression of protein disulfide isomerase (PDI) and Nox1 in resistance arteries correlates with the development of hypertension. Epidermal growth factor (EGF)-like ligands are increased in vascular disease and their levels… read more here.
Keywords: disulfide isomerase; protein disulfide; expression; hypertension ... See more keywords
Inhibition of protein disulfide isomerase has neuroprotective effects in a mouse model of experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106286
Abstract: Endoplasmic reticulum (ER) stress is strictly linked to neuroinflammation and involves in the development of neurodegenerative disorders. Protein disulfide isomerase (PDI) is an enzyme that catalyzes formation and isomerization of disulfide bonds and also acts… read more here.
Keywords: disulfide isomerase; protein disulfide; stress; autoimmune encephalomyelitis ... See more keywords
Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2083726
Abstract: Abstract Thrombosis occurs in both macrovasculature and microvasculature, causing various cardio-cerebral vascular diseases. The lack of effective and safe antithrombotic drugs leads to a public health crisis. Mounting evidence suggests that protein disulfide isomerase (PDI)… read more here.
Keywords: protein disulfide; based nano; lipid based; disulfide isomerase ... See more keywords
A conserved protein disulfide isomerase enhances plant resistance against herbivores.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac489
Abstract: Herbivore-associated molecular patterns (HAMPs) enable plants to recognize herbivores and may help plants adjust their defense responses. Here, we report on herbivore-induced changes in a protein disulfide isomerase (PDI) widely distributed across arthropods. PDI from… read more here.
Keywords: protein disulfide; isomerase enhances; disulfide isomerase; plant ... See more keywords
A new antithrombotic strategy: inhibition of the C‐terminal active site of protein disulfide isomerase
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13634
Abstract: Protein disulfide isomerase (PDI) was discovered over fifty years ago as an enzyme that forms disulfide bonds in newly synthesized proteins in the endoplasmic reticulum [1]. Twenty five years ago PDI was shown to be… read more here.
Keywords: disulfide isomerase; protein disulfide; strategy inhibition; new antithrombotic ... See more keywords
AC81 Is a Putative Disulfide Isomerase Involved in Baculoviral Disulfide Bond Formation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01167-22
Abstract: Many large DNA viruses, such as poxvirus, asfarvirus, and baculovirus, encode their own sulfhydryl oxidase to facilitate the disulfide bond formation of viral proteins. Here, we show that AC81 functions as a putative disulfide isomerase… read more here.
Keywords: formation; disulfide bond; bond formation; disulfide isomerase ... See more keywords
ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-4046
Abstract: This study uses a first-in-class PDI inhibitor entering clinical development to enhance the effects of epigenetic drugs in some of the deadliest forms of cancer. Histone deacetylase inhibitors (HDACi) are largely ineffective in the treatment… read more here.
Keywords: protein disulfide; epigenetic drugs; cancer; pdi ... See more keywords
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01116-z
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-linked mutant SOD1 develop… read more here.
Keywords: sod1; disulfide isomerase; protein disulfide; mutant sod1 ... See more keywords
Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260656
Abstract: ABSTRACT Proteins entering the secretory pathway need to attain native disulfide pairings to fold correctly. For proteins with complex disulfides, this process requires the reduction and isomerisation of non-native disulfides. Two key members of the… read more here.
Keywords: erp57 erdj5; role; erp57; disulfide isomerase ... See more keywords