Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide‐rich de novo designed peptides
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3453
Abstract: Disulfide‐rich peptides represent an important protein family with broad pharmacological potential. Recent advances in computational methods have made it possible to design new peptides which adopt a stable conformation de novo. Here, we describe a… read more here.
Keywords: novo designed; disulfide rich; solution; rich novo ... See more keywords
Disulfide-Rich Cyclic Peptides from Clitoria ternatea Protect against β-Amyloid Toxicity and Oxidative Stress in Transgenic Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00033
Abstract: Neurotoxic aggregation of β-amyloid (Aβ) peptides is a hallmark of Alzheimer's disease and increased reactive oxygen species (ROS) is an associated process. In the present study, we report the neuroprotective effects of disulfide-rich, circular peptides… read more here.
Keywords: transgenic caenorhabditis; disulfide rich; caenorhabditis elegans; toxicity ... See more keywords
An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides
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DOI: 10.1039/d0gc01366h
Abstract: Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and development. Current peptide production strategies rely heavily on solid phase peptide synthesis (SPPS) requiring large amounts of hazardous/toxic reagents and solvents which have negative… read more here.
Keywords: production; disulfide rich; production cyclic; rich peptides ... See more keywords
An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02952e
Abstract: Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. However, there are only a limited number of topologically distinct DRP folds in nature, and most of them suffer… read more here.
Keywords: evolution inspired; strategy design; disulfide; disulfide rich ... See more keywords
Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00924b
Abstract: Peptides constrained through multiple disulfides (or disulfide-rich peptides, DRPs) have been an emerging frontier for ligand and drug discovery. Such peptides have the potential to combine the binding capability of biologics with the stability and… read more here.
Keywords: structure; disulfide rich; peptide; discovery ... See more keywords
Selection and evolution of disulfide-rich peptides via cellular protein quality control
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05343h
Abstract: Disulfide-rich peptides (DRPs) are an interesting and promising molecular format for drug discovery and development. However, the engineering and application of DRPs rely on the foldability of the peptides into specific structures with correct disulfide… read more here.
Keywords: protein quality; quality control; rich peptides; disulfide rich ... See more keywords
Residual Dipolar Couplings for Resolving Cysteine Bridges in Disulfide-Rich Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00889
Abstract: Disulfide bridges in proteins are formed by the oxidation of pairs of cysteine residues. These cross-links play a critical role in stabilizing the 3D-structure of small disulfide rich polypeptides such as hormones and venom toxins.… read more here.
Keywords: resolution; residual dipolar; cysteine; disulfide rich ... See more keywords
The deep-rooted origin of disulfide-rich spider venom toxins
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.83761
Abstract: Spider venoms are a complex concoction of enzymes, polyamines, inorganic salts, and disulfide-rich peptides (DRPs). Although DRPs are widely distributed and abundant, their bevolutionary origin has remained elusive. This knowledge gap stems from the extensive… read more here.
Keywords: venom toxins; spider venom; disulfide rich; toxin ... See more keywords