Microenvironmental Self‐Optimizing HOFs Biocatalysts for Boosting Disulfidptosis‐Mediated Antitumor Immunotherapy
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DOI: 10.1002/adfm.202512644
Abstract: Disulfidptosis, a novel programmed cell death mechanism triggered by glucose deprivation in solute carrier family 7 member 11 (SLC7A11)‐overexpressing tumors, facilitates the release of tumor‐associated antigens (TAAs) and activates immune responses, providing a new strategy… read more here.
Keywords: mediated antitumor; disulfidptosis; immunotherapy; disulfidptosis mediated ... See more keywords
Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation
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DOI: 10.1002/advs.202408556
Abstract: Disulfidptosis, a novel form of regulated cell death, involves cytoskeletal collapse due to excessive disulfide bond formation, linking metabolism and reactive oxygen species to potential cancer therapy targets. Recent multi‐omics studies highlight the prognostic value… read more here.
Keywords: cancer; drg score; disulfidptosis; slc7a11 inf2 ... See more keywords
Bidirectional Regulatory Mechanisms of Disulfidptosis Govern Precision Targeting in Degenerative Bone Diseases and Osteosarcoma
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DOI: 10.1002/jcp.70100
Abstract: Disulfidptosis is a newly identified form of programmed cell death closely associated with cystine metabolism abnormalities and cytoskeletal damage. Orthopedic diseases, such as degenerative conditions including intervertebral disc degeneration, osteoporosis, osteoarthritis, and malignant bone tumors… read more here.
Keywords: disulfidptosis; precision; orthopedic diseases; bidirectional regulatory ... See more keywords
Identification of a novel molecular classification for hepatocellular carcinoma based on disulfideptosis-related genes and its potential prognostic significance
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DOI: 10.1007/s00432-024-06031-7
Abstract: Globally, hepatocellular carcinoma (HCC) is one of the most prevalent and deadly malignant tumors. A recent study proposed disulfidptosis, a novel form of regulated cell death (RCD), offering a new avenue for identifying tumor prognosis… read more here.
Keywords: related genes; disulfideptosis related; disulfidptosis score; disulfidptosis ... See more keywords
The involvement of lncRNA EMSLR in the disulfidptosis and progression of endometrial carcinoma
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DOI: 10.1038/s41417-025-00918-4
Abstract: The incidence of endometrial cancer (EC) continues to rise. Disulfidptosis, a novel form of cell death, may represent a potential therapeutic target in EC. Through bioinformatic analysis of The Cancer Genome Atlas (TCGA) database, E2F1… read more here.
Keywords: cancer; lncrna emslr; disulfidptosis; progression ... See more keywords
Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power
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DOI: 10.1038/s41467-025-60015-w
Abstract: Disulfidptosis, a recently identified form of programmed cell death, is initiated by depletion of endogenous nicotinamide adenine dinucleotide phosphate (NADPH) under glucose starvation. Tumor cells, owing to their heightened requirements of energy and nutrients, are… read more here.
Keywords: disulfidptosis; cellular energy; energy supply; tumor ... See more keywords
Development of a novel disulfidptosis-related lncRNA signature for prognostic and immune response prediction in clear cell renal cell carcinoma
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DOI: 10.1038/s41598-024-51197-2
Abstract: Disulfidptosis, a novel form of regulated cell death, occurs due to the aberrant accumulation of intracellular cystine and other disulfides. Moreover, targeting disulfidptosis could identify promising approaches for cancer treatment. Long non-coding RNAs (lncRNAs) are… read more here.
Keywords: related lncrnas; disulfidptosis; risk; signature ... See more keywords
A disulfidptosis-related lncRNA signature for predicting prognosis and evaluating the tumor immune microenvironment of lung adenocarcinoma
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DOI: 10.1038/s41598-024-55201-7
Abstract: As a novel form of regulated cell death (RCD), disulfidptosis offering a significant opportunity in better understanding of tumor pathogenesis and therapeutic strategies. Long non-coding RNAs (lncRNAs) regulate the biology functions of tumor cells by… read more here.
Keywords: disulfidptosis; lung adenocarcinoma; risk; tumor ... See more keywords
Development and validation of a novel disulfidptosis-related lncRNAs signature in patients with HPV-negative oral squamous cell carcinoma
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DOI: 10.1038/s41598-024-65194-y
Abstract: Disulfidptosis is a recently identified mode of regulated cell death. Regulating disulfidptosis in carcinoma is a promising therapeutic approach. Long non-coding RNAs (lncRNAs) have been reported to be related to the occurrence and development of… read more here.
Keywords: disulfidptosis; analysis; signature; validation ... See more keywords
Development of a disulfidptosis-related lncRNA prognostic signature for enhanced prognostic assessment and therapeutic strategies in lung squamous cell carcinoma
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DOI: 10.1038/s41598-024-68423-6
Abstract: Limited treatment options and poor prognosis present significant challenges in the treatment of lung squamous cell carcinoma (LUSC). Disulfidptosis impacts cancer progression and prognosis. We developed a prognostic signature using disulfidptosis-related long non-coding RNAs (lncRNAs)… read more here.
Keywords: disulfidptosis; cell carcinoma; prognosis; squamous cell ... See more keywords
Identification of a disulfidptosis-related genes signature for diagnostic and immune infiltration characteristics in endometriosis
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DOI: 10.1038/s41598-024-77539-8
Abstract: Endometriosis (EMs) is the prevalent gynecological disease with the typical features of intricate pathogenesis and immune-related factors. Currently, there is no effective therapeutic intervention for EMs. Disulfidptosis, the cell death pattern discovered recently, may show… read more here.
Keywords: disulfidptosis; related genes; analysis; genes signature ... See more keywords