Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.04.019
Abstract: Obesity is a top public health concern, and a molecule that safely treats obesity is urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties and helps protect… read more here.
Keywords: disulfiram; treatment; obesity; disulfiram treatment ... See more keywords
Disulfiram/copper shows potent cytotoxic effects on myelodysplastic syndromes via inducing Bip-mediated apoptosis and suppressing autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174107
Abstract: Patients with myelodysplastic syndromes (MDS) who resist or fail to respond to hypomethylating agents (HMAs) show very poor outcomes and have no effective treatment strategies. Therefore, new therapeutic approaches are urgently needed for MDS patients… read more here.
Keywords: myelodysplastic syndromes; cytotoxic effects; dsf; shows potent ... See more keywords
Repurposing disulfiram for treatment of Staphylococcus aureus infections.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.03.024
Abstract: BACKGROUND Antimicrobial resistance is an urgent threat affecting healthcare systems worldwide. Identification of novel molecules capable of escaping current resistance mechanisms and exhibiting potent activity against highly drug-resistant strains is the unmet need of the… read more here.
Keywords: repurposing disulfiram; disulfiram; staphylococcus aureus; disulfiram treatment ... See more keywords
82. Disulfiram inhibits placental sFLT-1 secretion
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.208
Abstract: Introduction Preeclampsia is associated with elevated placental secretion of the anti-angiogenic factor sFLT-1. Surprisingly, little is understood about its regulation, identifying such mechanisms may uncover therapeutic leads. Objectives Our objective was to determine the effects… read more here.
Keywords: sflt secretion; disulfiram; secretion; endothelial dysfunction ... See more keywords
Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2018.09.005
Abstract: Preeclampsia is associated with intermittent placental hypoxia, inflammation and the release of antiangiogenic factors, namely sFLT-1 and sEng. These factors cause maternal endothelial dysfunction and the manifestation of clinical disease. Disulfiram is a dehydrogenase inhibitor… read more here.
Keywords: secretion; disulfiram inhibits; disulfiram; expression ... See more keywords
Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ aging and mechanisms of disease"
DOI: 10.1038/s41514-020-0046-6
Abstract: There is an unmet need and urgency to find safe and effective anti-obesity interventions. Our recent study in mice fed on obesogenic diet found that treatment with the alcohol aversive drug disulfiram reduced feeding efficiency… read more here.
Keywords: protects obesity; elucidating mechanisms; disulfiram protects; disulfiram ... See more keywords
Copper (α)/cis-platinum-loaded nanogels as an adjuvant potentiate disulfiram's antitumor efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01795k
Abstract: Disulfiram (DSF) is nontoxic and exerts anticancer activity by forming highly toxic chelates via its metabolite diethyldithiocarbamate with transition metal ions. However, there are not enough such ions in the human body to maintain the… read more here.
Keywords: disulfiram; antitumor efficacy; copper; cis platinum ... See more keywords
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2098764
Abstract: Abstract Acute kidney injury (AKI) is a serious condition with high mortality. The most common cause is kidney ischemia/reperfusion (IR) injury, which is thought to be closely related to pyroptosis. Disulfiram is a well-known alcohol… read more here.
Keywords: injury; pyroptosis; disulfiram; caspase gsdmd ... See more keywords
Antibacterial activity of disulfiram and its metabolites
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.14094
Abstract: Disulfiram (Antabuse™) and its metabolites formed in vivo were evaluated as antibacterial agents against thirty species of Gram‐positive and Gram‐negative bacteria. The synergistic potential of disulfiram (DSF) and metabolite diethyldithiocarbamate (DDTC) with approved antibiotics were… read more here.
Keywords: antibacterial activity; disulfiram; disulfiram metabolites; activity disulfiram ... See more keywords
Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0236119
Abstract: The alcohol-abuse drug disulfiram has antitumor effects against diverse cancer types via inhibition of the ubiquitin-proteasome protein nuclear protein localization protein 4 (NPL4). However, the antitumor effects of NPL4 and disulfiram in clear cell renal… read more here.
Keywords: cell renal; renal cell; disulfiram; treatment ... See more keywords
Recognition of a disulfiram ethanol reaction in the emergency department is not always straightforward
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0243222
Abstract: Objectives Disulfiram is an adjunct in the treatment of alcohol use disorders, but case reports indicate that disulfiram ethanol reactions are not always recognized in the emergency department. Our first aim is to remind of… read more here.
Keywords: disulfiram ethanol; disulfiram; emergency department; emergency ... See more keywords