Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.
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DOI: 10.1016/j.preghy.2018.09.005
Abstract: Preeclampsia is associated with intermittent placental hypoxia, inflammation and the release of antiangiogenic factors, namely sFLT-1 and sEng. These factors cause maternal endothelial dysfunction and the manifestation of clinical disease. Disulfiram is a dehydrogenase inhibitor… read more here.
Keywords: secretion; disulfiram inhibits; disulfiram; expression ... See more keywords