New Disulphide Bond in Cystatin-Based Protein Scaffold Prevents Domain-Swap-Mediated Oligomerization and Stabilizes the Functionally Active Form
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b02269
Abstract: Peptide aptamers built using engineered scaffolds are a valuable alternative to monoclonal antibodies in many research applications because of their smaller size, versatility, specificity for chosen targets, and ease of production. However, inserting peptides needed… read more here.
Keywords: protein scaffold; based protein; disulphide bond; bond ... See more keywords
Deleting the first disulphide bond in an arenicin derivative enhances its expression in Pichia pastoris
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DOI: 10.1111/lam.12770
Abstract: The marine antimicrobial peptide NZ17074, a variant of arenicin‐3 from Arenicola marina that has broad antimicrobial activity and high bioavailability, can be designed to treat bacterial and fungal diseases. To reduce the toxicity of NZ17074,… read more here.
Keywords: disulphide bond; antimicrobial activity; first disulphide; arenicin ... See more keywords