Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13005
Abstract: We determined the short‐term (i.e. 4 days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted‐fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB]. read more here.
Keywords: muscle protein; disuse atrophy; muscle; protein synthesis ... See more keywords
Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Physiology - Endocrinology and Metabolism"
DOI: 10.1152/ajpendo.00161.2019
Abstract: Skeletal muscle atrophy is a clinically important outcome of disuse because of injury, immobilization, or bed rest. Disuse atrophy is accompanied by mitochondrial dysfunction, which likely contributes to activation of the muscle atrophy program. However,… read more here.
Keywords: muscle; disuse atrophy; mitochondrial energetics; atrophy ... See more keywords
TESTOSTERONE SUPPRESSION DOES NOT EXACERBATE DISUSE ATROPHY AND IMPAIRS MUSCLE RECOVERY THAT IS NOT RESCUED BY HIGH PROTEIN.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00752.2019
Abstract: Androgen deprivation therapy (ADT) decreases muscle mass, force, and physical activity levels but it is unclear if disuse atrophy and testosterone suppression are additive. Additionally, conflicting reports exist on load-mediated hypertrophy during ADT and if… read more here.
Keywords: muscle; mass; testosterone suppression; disuse atrophy ... See more keywords
MicroRNA cargo of extracellular vesicles from skeletal muscle fibro-adipogenic progenitor cells is altered with disuse atrophy and IL-1β deficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00177.2021
Abstract: Fibro-adipogenic progenitor cells (FAPs) are a population of stem cells in skeletal muscle that play multiple roles in muscle repair and regeneration through their complex secretome; however, it is not well understood how the FAP… read more here.
Keywords: cargo; extracellular vesicles; fibro adipogenic; muscle ... See more keywords
Mitochondrial dysregulation and muscle disuse atrophy
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DOI: 10.12688/f1000research.19139.1
Abstract: It is well established that mitochondria play a critical role in the metabolic and physiological adaptation of skeletal muscle to enhanced contractile activity. Several redox-sensitive signaling pathways such as PGC-1α, AMPK, IGF/Akt/mTOR, SIRT, NFκB, and… read more here.
Keywords: mitochondrial dysregulation; muscle disuse; muscle; dysregulation muscle ... See more keywords
Construction and Analysis of Disuse Atrophy Model of the Gastrocnemius Muscle in Chicken
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DOI: 10.3390/ijms23136892
Abstract: Disuse muscle atrophy is identified as the physiological, biochemical, morphological, and functional changes during restricted movement, immobilization, or weightlessness. Although its internal mechanism has been extensively studied in mammals and was thought to be mainly… read more here.
Keywords: atrophy model; oxidative stress; muscle; disuse atrophy ... See more keywords