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   Articles with "diterpene" as a keyword



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Antimicrobial and cytotoxic effects of the Copaifera reticulata oleoresin and its main diterpene acids.

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recommendations! Published in 2019 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2018.11.029

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The oleoresin of Brazilian Copaifera reticulata is a traditional remedy used for the treatment of skin and urinary tract infections, respiratory diseases, rheumatism, ulcer and tumours; thus, playing an important role in the… read more here.

Keywords: diterpene acids; reticulata oleoresin; copaifera reticulata; diterpene ... See more keywords
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Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-one Ring from the Zoanthid-Derived Fungus Curvularia hawaiiensis TA26-15.

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recommendations! Published in 2019 at "Journal of natural products"

DOI: 10.1021/acs.jnatprod.9b00164

Abstract: Six new sordarin tetracyclic diterpene glycosides, moriniafungins B-G (1-6), and a new sordaricin tetracyclic diterpene, sordaricin B (8), together with two known analogues, moriniafungin (7) and sordaricin (9), were isolated from the zoanthid-derived fungus Curvularia… read more here.

Keywords: derived fungus; fungus curvularia; zoanthid derived; diterpene glycosides ... See more keywords
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Identification and Characterization of a Cryptic Bifunctional Type I Diterpene Synthase Involved in Talaronoid Biosynthesis from a Marine-Derived Fungus

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recommendations! Published in 2022 at "Organic Letters"

DOI: 10.1021/acs.orglett.2c02904

Abstract: We report the identification of the tnd biosynthetic cluster from the marine-derived fungus Aspergillus flavipes and the in vivo characterization of a cryptic type I diterpene synthase. The heterologous expression of the bifunctional terpene synthase… read more here.

Keywords: diterpene; derived fungus; characterization cryptic; type diterpene ... See more keywords
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Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.

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recommendations! Published in 2017 at "ACS chemical biology"

DOI: 10.1021/acschembio.7b00154

Abstract: The diterpene cyclase CotB2 catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to the tricyclic cyclooctat-9-en-7-ol, which is characterized by a 5-8-5-fused ring skeleton. We have previously proposed a cyclization cascade involving a unique carbon-carbon bond… read more here.

Keywords: geranylgeranyl diphosphate; cyclization geranylgeranyl; geranylgeranyl; cyclization ... See more keywords
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A novel diterpene agent isolated from Microbispora hainanensis strain CSR-4 and its in vitro and in silico inhibition effects on acetylcholine esterase enzyme

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-68009-y

Abstract: An actinomycete strain CSR-4 was isolated from the rhizosphere soil of Zingiber montanum. Taxonomic characterization revealed strain CSR-4 was a member of the genus Microbispora. Whole-genome sequence analysis exhibited the highest average nucleotide identity (ANI)… read more here.

Keywords: strain csr; diterpene; compound; hainanensis ... See more keywords
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Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish

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recommendations! Published in 2019 at "Drug and Chemical Toxicology"

DOI: 10.1080/01480545.2019.1586916

Abstract: Abstract Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids… read more here.

Keywords: heart rates; diterpene alkaloids; diterpene; cardiotoxicity ... See more keywords
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New 6(17)-epoxylathyrane diterpene: aellinane from Euphorbia aellenii induces apoptosis via mitochondrial pathway in ovarian cancer cell line

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recommendations! Published in 2017 at "Toxicology Mechanisms and Methods"

DOI: 10.1080/15376516.2017.1347735

Abstract: Abstract Euphorbia species have been used in traditional medicine in many countries for the treatment of cancer. This article aims to evaluate the capability of a new lathyrane diterpene isolated from Euphorbia aellenii to induce… read more here.

Keywords: lathyrane diterpene; diterpene; caov cells; euphorbia aellenii ... See more keywords
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A Fungal Diterpene Synthase Is Responsible for Sterol Biosynthesis for Growth

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recommendations! Published in 2020 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2020.01426

Abstract: A conserved open reading frame, dps, is described in Pestalotiopsis microspora, sharing a remarkable similarity with fungal diterpene synthases whose function is less studied. Loss-of-function approach manifested that dps was necessary for the growth and… read more here.

Keywords: synthase responsible; responsible sterol; diterpene; fungal diterpene ... See more keywords