Antimicrobial and cytotoxic effects of the Copaifera reticulata oleoresin and its main diterpene acids.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.11.029
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The oleoresin of Brazilian Copaifera reticulata is a traditional remedy used for the treatment of skin and urinary tract infections, respiratory diseases, rheumatism, ulcer and tumours; thus, playing an important role in the… read more here.
Keywords: diterpene acids; reticulata oleoresin; copaifera reticulata; diterpene ... See more keywords
Hericinosides A-M, Cyathane Diterpene Glycosides with α-Glucosidase Inhibitory Activity from the Medicinal Fungus Hericium erinaceus.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c10986
Abstract: Thirteen new cyathane diterpene glycosides, hericinosides A-M (1-13), and six known analogs, were isolated from the rice media fermentation of the medicinal fungus Hericium erinaceus. The sugar parts of 1 and 2 were highly modified,… read more here.
Keywords: fungus hericium; medicinal fungus; diterpene glycosides; cyathane diterpene ... See more keywords
Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-one Ring from the Zoanthid-Derived Fungus Curvularia hawaiiensis TA26-15.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00164
Abstract: Six new sordarin tetracyclic diterpene glycosides, moriniafungins B-G (1-6), and a new sordaricin tetracyclic diterpene, sordaricin B (8), together with two known analogues, moriniafungin (7) and sordaricin (9), were isolated from the zoanthid-derived fungus Curvularia… read more here.
Keywords: derived fungus; fungus curvularia; zoanthid derived; diterpene glycosides ... See more keywords
Identification and Characterization of a Cryptic Bifunctional Type I Diterpene Synthase Involved in Talaronoid Biosynthesis from a Marine-Derived Fungus
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c02904
Abstract: We report the identification of the tnd biosynthetic cluster from the marine-derived fungus Aspergillus flavipes and the in vivo characterization of a cryptic type I diterpene synthase. The heterologous expression of the bifunctional terpene synthase… read more here.
Keywords: diterpene; derived fungus; characterization cryptic; type diterpene ... See more keywords
Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00154
Abstract: The diterpene cyclase CotB2 catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to the tricyclic cyclooctat-9-en-7-ol, which is characterized by a 5-8-5-fused ring skeleton. We have previously proposed a cyclization cascade involving a unique carbon-carbon bond… read more here.
Keywords: geranylgeranyl diphosphate; cyclization geranylgeranyl; geranylgeranyl; cyclization ... See more keywords
A novel diterpene agent isolated from Microbispora hainanensis strain CSR-4 and its in vitro and in silico inhibition effects on acetylcholine esterase enzyme
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68009-y
Abstract: An actinomycete strain CSR-4 was isolated from the rhizosphere soil of Zingiber montanum. Taxonomic characterization revealed strain CSR-4 was a member of the genus Microbispora. Whole-genome sequence analysis exhibited the highest average nucleotide identity (ANI)… read more here.
Keywords: strain csr; diterpene; compound; hainanensis ... See more keywords
Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2019.1586916
Abstract: Abstract Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids… read more here.
Keywords: heart rates; diterpene alkaloids; diterpene; cardiotoxicity ... See more keywords
Synthesis and bioevaluation of water-soluble β-cyclodextrin–diterpene acid conjugates
Sign Up to like & getrecommendations! Published in 2024 at "Natural Product Research"
DOI: 10.1080/14786419.2024.2347449
Abstract: Abstract A series of β-cyclodextrin (β-CD)-conjugates were prepared by combining three abietane-type diterpene acids with two azide-functionalized β-CDs via click chemistry, and the antiviral activity against wild-type and omicron SARS–CoV-2 spike pseudovirus as well as… read more here.
Keywords: synthesis bioevaluation; diterpene acid; bioevaluation water; cyclodextrin ... See more keywords
New 6(17)-epoxylathyrane diterpene: aellinane from Euphorbia aellenii induces apoptosis via mitochondrial pathway in ovarian cancer cell line
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2017.1347735
Abstract: Abstract Euphorbia species have been used in traditional medicine in many countries for the treatment of cancer. This article aims to evaluate the capability of a new lathyrane diterpene isolated from Euphorbia aellenii to induce… read more here.
Keywords: lathyrane diterpene; diterpene; caov cells; euphorbia aellenii ... See more keywords
Abstract 62: Effect of Ginkgo Diterpene Lactone Meglumine on Cognitive Function in Patients With Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2024 at "Stroke"
DOI: 10.1161/str.55.suppl_1.62
Abstract: Objective: To investigate the effect of ginkgo diterpene lactone meglumine injection on cognitive function in patients with acute ischemic stroke. Methods: This was a randomized, double-blind, placebo parallel-controlled, multicenter clinical trial. Patients with acute ischemic… read more here.
Keywords: diterpene lactone; ginkgo diterpene; patients acute; group ... See more keywords
Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of Vachellia nilotica
Sign Up to like & getrecommendations! Published in 2024 at "Open Chemistry"
DOI: 10.1515/chem-2024-0005
Abstract: Abstract A new labdane diterpene characterized as 18α-O-trans-p-feruloyl-15-methyl-8(17)-labdanoate has been isolated from the roots of Vachellia nilotica. Also isolated were p-coumaric acid, ferulic acid, stearic acid, lupeol, and a mixture of β-sitosterol and stigmasterol. The… read more here.
Keywords: vachellia nilotica; labdane diterpene; anti parasitic; activity ... See more keywords