A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy.
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DOI: 10.1039/c9cc05438c
Abstract: Here, we report the rational design of a H2O2-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(ii) to form Cu(DTC)2 with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity… read more here.
Keywords: stress amplification; dithiocarbamate based; h2o2 responsive; oxidative stress ... See more keywords