A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05438c
Abstract: Here, we report the rational design of a H2O2-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(ii) to form Cu(DTC)2 with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity… read more here.
Keywords: stress amplification; dithiocarbamate based; h2o2 responsive; oxidative stress ... See more keywords
Structural insights and in vitro and in vivo anticancer evaluation of dithiocarbamate-based metal complexes against murine lymphoma.
Sign Up to like & getrecommendations! Published in 2025 at "Dalton transactions"
DOI: 10.1039/d5dt00666j
Abstract: Metal-based chemotherapeutics have gained attention due to their ability to interfere with cellular functions. Dithiocarbamate ligands, known for their strong metal-binding properties, have been explored for their potential in anticancer applications. This study aims to… read more here.
Keywords: dithiocarbamate based; anticancer; metal; vitro vivo ... See more keywords