On the plasticizing properties of divalproex sodium: physicochemical and spectroscopic characterization studies
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2018.1514049
Abstract: Abstract The objective of the research was to demonstrate the plasticization properties of divalproex sodium, due to its component—valproic acid, on ethyl cellulose, which could prove beneficial for film fabrications or hot melt extrusion based… read more here.
Keywords: divalproex sodium; microscopy; presence; properties divalproex ... See more keywords
A Validated GC-MS Method for the Determination of Genotoxic Impurities in Divalproex Sodium Drug Substance.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmy089
Abstract: A specific GC-MS method has been developed, optimized and validated for the determination of five genotoxic impurities namely Methyl bromide (Me.-Br), Ethyl bromide (Et.-Br), Isopropyl bromide (Ipr.-Br), n-Propyl bromide (n-Pr.-Br) and n-Butyl bromide (n-But.-Br) in… read more here.
Keywords: determination; drug substance; divalproex sodium; genotoxic impurities ... See more keywords
Fixed Dose Combination Tablets of Aripiprazole and Divalproex Sodium: a Pilot Pharmacokinetic Study in Human Volunteers
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02378-7
Abstract: A combination product of aripiprazole (antipsychotic) and divalproex sodium (mood stabilizer) was recently developed to establish their tolerability and safety in fixed dose combination (FDC). A pilot pharmacokinetic (PK) open-labeled parallel study on healthy human… read more here.
Keywords: combination; sodium; pilot; aripiprazole divalproex ... See more keywords