Divergent Asymmetric Synthesis of Chiral Spiroheterocycles through Pd-Catalyzed Enantio- and Diastereoselective [3 + 2] Spiroannulation.
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DOI: 10.1021/acs.orglett.2c03643
Abstract: The palladium-catalyzed divergent asymmetric synthesis of chiral spiro-furanindoline derivatives is described. The zwitterionic alkoxy π-allyl Pd(II) intermediate, generated catalytically from vinyl ethylene carbonate (VEC), could undergo ligand-controlled enantio- and diastereoselective dipolar [3 + 2] spiroannulation… read more here.
Keywords: spiroannulation; enantio diastereoselective; synthesis chiral; divergent asymmetric ... See more keywords
Divergent Asymmetric Total Syntheses of (-)-Alloaristoteline and (+)-Aristoteline via Directed Indolization Strategies.
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DOI: 10.1021/acs.orglett.3c01224
Abstract: A divergent asymmetric synthetic route to (-)-alloaristoteline and (+)-aristoteline is described. The key doubly bridged tricyclic enol triflate common intermediate prepared via enantioselective deprotonation and stepwise annulation was successfully bifurcated to complete the first completely… read more here.
Keywords: directed indolization; total syntheses; alloaristoteline aristoteline; asymmetric total ... See more keywords