Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization
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DOI: 10.1016/j.tet.2017.02.057
Abstract: Abstract An efficient diastereoselective approach to access trans-5-hydroxy-6-substituted 2-piperidinones skeleton has been developed through one-pot intramolecular tandem process of O-benzyl protected aldimine 11 with Grignard reagents. The diastereoselectivity of substitution at C-6 position of 2-piperidinone… read more here.
Keywords: syntheses 733; 733 060; one pot; tandem ... See more keywords
Modular and Divergent Syntheses of Protoberberine and Protonitidine Alkaloids.
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DOI: 10.1021/acs.orglett.0c04310
Abstract: A modularly convergent and divergent strategy was established for the family synthesis of both protoberberine and protonitidine alkaloids. The robust, scalable, and flexible synthetic route featured a collective preparation of protoberberine and protonitidine alkaloids from… read more here.
Keywords: modular divergent; protoberberine protonitidine; syntheses protoberberine; protonitidine alkaloids ... See more keywords
Alkynyl triazenes enable divergent syntheses of 2-pyronesâ€
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DOI: 10.1039/d1sc02583j
Abstract: The 2-pyrone motif occurs frequently in bioactive natural products and is appreciated as synthetic intermediates. However, only few methods allow for diversifying functional group modifications on this relevant heterocycle. The distinct properties of 1-alkynyl triazenes… read more here.
Keywords: syntheses pyrones; triazenes enable; enable divergent; group ... See more keywords