Divergent Synthesis of Novel 3(5)‐Aminoazole–Benzopyrone Hybrids and their Evaluation as α‐Glucosidase Inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400525
Abstract: An efficient approach has been developed for the trapping in situ generated benzopyrone‐based ortho‐quinone methide intermediates by 3‐ and 5‐amino pyrazoles or isoxazoles. In cases of naturally occurring phenolic Mannich bases, hybrid compounds between the azole… read more here.
Keywords: synthesis novel; aminoazole benzopyrone; divergent synthesis; glucosidase ... See more keywords
Divergent Synthesis of Isoxazolo[5,4‐b]pyridines
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202301287
Abstract: Isoxazolopyridines are highly significant for the development of pharmaceutics and new materials. In continuation of our ongoing research on transformations of 5‐aminoisoxazoles, herein we report a divergent synthesis of two kinds of novel isoxazolo[5,4‐b]pyridines via… read more here.
Keywords: divergent synthesis; isoxazolo pyridines; synthesis isoxazolo; chemistry ... See more keywords
Divergent synthesis of functionalized thioethers via multicomponent reaction of benzynes
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.072
Abstract: Abstract Diverse functionalized thioethers were efficiently synthesized through the multicomponent reaction of benzynes, cyclic thioethers and different nucleophiles. Both inorganic salts (KF, KCl, KBr, and KSCN) and silylated reagents (TMSCN, TMSN3, TMSCl) can be utilized… read more here.
Keywords: divergent synthesis; multicomponent reaction; functionalized thioethers; synthesis functionalized ... See more keywords
Divergent synthesis of functionalized dihydropyridines and pyrroles via metal-free one-pot domino reactions of a gem-disubstituted propargyl amine and an alkynyl sulfone
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153283
Abstract: Abstract Reaction of an 2-amino-2-ethynylmalonate derivative with an ethynyl sulfone allowed metal-free divergent synthesis of 1,6-dihydropyridines (DHPs) and 3,5-disubstituted pyrroles in one-pot. This facile atom-economical domino process involves hetero-conjugate addition and subsequent propargyl aza-Claisen-type rearrangement,… read more here.
Keywords: metal free; sulfone; divergent synthesis; one pot ... See more keywords
Fluorinated Radicals in Divergent Synthesis via Photoredox Catalysis
Sign Up to like & getrecommendations! Published in 2025 at "Accounts of Chemical Research"
DOI: 10.1021/acs.accounts.5c00239
Abstract: Conspectus Fluorine is an essential element in pharmaceuticals, agrochemicals, and material sciences, significantly enhancing the bioactivity, metabolic stability, and physicochemical properties of organic molecules. In medicinal chemistry, nearly 20% of marketed drugs contain at least… read more here.
Keywords: chemistry; divergent synthesis; synthesis; fluorine ... See more keywords
Divergent Synthesis of Six Recent Berkeleylactones.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00053
Abstract: The six recently isolated berkeleylactones E, J, K, M, N, and O were synthesized for the first time by a divergent strategy starting from a common intermediate in our synthesis of berkeleylactone A. Key features… read more here.
Keywords: recent berkeleylactones; synthesis six; six recent; synthesis ... See more keywords
Divergent Synthesis of Double Heterohelicenes as Strong Chiral Double Hydrogen-Bonding Donors.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02734
Abstract: We developed a very efficient and expandable divergent approach initiated by a direct electrophilic borylation at phenyl rings to synthesize a series of double heterohelicenes. Their π-extended structures with pristine zigzag nitrogen (N)-boron (B)-nitrogen (N)… read more here.
Keywords: hydrogen bonding; synthesis double; divergent synthesis; hydrogen ... See more keywords
Divergent Synthesis of Pentacyclic Isoindolinones Enabled by Sequential Insertion of Two Different Isocyanides and Acid Promoted Cyclization of Ketenimines.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00393
Abstract: A palladium-catalyzed multicomponent reaction involving o-bromobenzaldehydes and two different isocyanides was developed to assemble series of isoindolinones with spiroindolenine or azepinoindole skeletons. This sequential insertion reaction features mild conditions, a wide substrate scope, and high… read more here.
Keywords: synthesis pentacyclic; two different; sequential insertion; different isocyanides ... See more keywords
Modular Divergent Synthesis of Functionalized Indoles via TFA-Promoted Amino-Claisen Rearrangement at Room Temperature.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00764
Abstract: A conceptually novel approach for the modular and divergent synthesis of highly functionalized indoles via trifluoroacetic acid-promoted amino-Claisen rearrangement is reported. This metal-free protocol could be performed at room temperature with wide functional group tolerance.… read more here.
Keywords: amino claisen; functionalized indoles; divergent synthesis; indoles via ... See more keywords
Divergent Synthesis of Symmetric Benzenes and Fluorenones.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c01804
Abstract: The benzene ring is a prevalent core structure in both biologically significant compounds and functional materials. This prompts the development of innovative methods for synthesizing benzene derivatives. We present a divergent synthetic strategy for accessing… read more here.
Keywords: benzenes fluorenones; divergent synthesis; synthesis symmetric; symmetric benzenes ... See more keywords
Controllable Defluorinative Cyclization for Divergent Synthesis of Pyrrolo[2,3-d]pyrimidines and Fluorinated Pyrimidines from β-CF3-1,3-Enynes and Amidine Hydrochlorides.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02345
Abstract: This study successfully developed a novel controllable defluorinative cyclization strategy for β-CF3-1,3-enynes, achieving the divergent synthesis of pyrrolo[2,3-d]pyrimidines and fluorinated pyrimidines. The reaction between β-CF3-1,3-enynes and amidine hydrochlorides at a 1:2 molar ratio triggered selective… read more here.
Keywords: pyrrolo; divergent synthesis; defluorinative cyclization; cf3 enynes ... See more keywords