Divergent synthesis of functionalized thioethers via multicomponent reaction of benzynes
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.072
Abstract: Abstract Diverse functionalized thioethers were efficiently synthesized through the multicomponent reaction of benzynes, cyclic thioethers and different nucleophiles. Both inorganic salts (KF, KCl, KBr, and KSCN) and silylated reagents (TMSCN, TMSN3, TMSCl) can be utilized… read more here.
Keywords: divergent synthesis; multicomponent reaction; functionalized thioethers; synthesis functionalized ... See more keywords
Divergent synthesis of functionalized dihydropyridines and pyrroles via metal-free one-pot domino reactions of a gem-disubstituted propargyl amine and an alkynyl sulfone
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153283
Abstract: Abstract Reaction of an 2-amino-2-ethynylmalonate derivative with an ethynyl sulfone allowed metal-free divergent synthesis of 1,6-dihydropyridines (DHPs) and 3,5-disubstituted pyrroles in one-pot. This facile atom-economical domino process involves hetero-conjugate addition and subsequent propargyl aza-Claisen-type rearrangement,… read more here.
Keywords: metal free; sulfone; divergent synthesis; one pot ... See more keywords
Divergent Synthesis of Six Recent Berkeleylactones.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00053
Abstract: The six recently isolated berkeleylactones E, J, K, M, N, and O were synthesized for the first time by a divergent strategy starting from a common intermediate in our synthesis of berkeleylactone A. Key features… read more here.
Keywords: recent berkeleylactones; synthesis six; six recent; synthesis ... See more keywords
Divergent Synthesis of Double Heterohelicenes as Strong Chiral Double Hydrogen-Bonding Donors.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02734
Abstract: We developed a very efficient and expandable divergent approach initiated by a direct electrophilic borylation at phenyl rings to synthesize a series of double heterohelicenes. Their π-extended structures with pristine zigzag nitrogen (N)-boron (B)-nitrogen (N)… read more here.
Keywords: hydrogen bonding; synthesis double; divergent synthesis; hydrogen ... See more keywords
Divergent Synthesis of Pentacyclic Isoindolinones Enabled by Sequential Insertion of Two Different Isocyanides and Acid Promoted Cyclization of Ketenimines.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00393
Abstract: A palladium-catalyzed multicomponent reaction involving o-bromobenzaldehydes and two different isocyanides was developed to assemble series of isoindolinones with spiroindolenine or azepinoindole skeletons. This sequential insertion reaction features mild conditions, a wide substrate scope, and high… read more here.
Keywords: synthesis pentacyclic; two different; sequential insertion; different isocyanides ... See more keywords
Modular Divergent Synthesis of Functionalized Indoles via TFA-Promoted Amino-Claisen Rearrangement at Room Temperature.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00764
Abstract: A conceptually novel approach for the modular and divergent synthesis of highly functionalized indoles via trifluoroacetic acid-promoted amino-Claisen rearrangement is reported. This metal-free protocol could be performed at room temperature with wide functional group tolerance.… read more here.
Keywords: amino claisen; functionalized indoles; divergent synthesis; indoles via ... See more keywords
Atomically Dispersed Co-N/C Catalyst for Divergent Synthesis of Nitrogen-Containing Compounds from Alkenes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12344
Abstract: Alkene functionalization with a single-atom catalyst (SAC) which merges homogeneous and heterogeneous catalysis is a fascinating route to obtain high-value-added molecules. However, C-N bond formation of alkene with SAC is still unexplored. Herein, a bimetal-organic… read more here.
Keywords: atomically dispersed; catalyst divergent; catalyst; synthesis nitrogen ... See more keywords
Retracted Article: Divergent synthesis of 5-substituted pyrimidine 2′-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc04161k
Abstract: Recent studies have indicated that 5-methylcytosine (5mC) residues in DNA can be oxidized and potentially deaminated to the corresponding thymine analogs. Some of these oxidative DNA damages have been implicated as new epigenetic markers that… read more here.
Keywords: divergent synthesis; dna; retracted article; article divergent ... See more keywords
Divergent synthesis of α-functionalized amides through selective N-O/C-C or N-O/C-C/C-N cleavage of aza-cyclobutanone oxime esters.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03348d
Abstract: Herein, a novel sequential ring opening reaction of aza-cyclobutanone oxime esters with isocyanides is described. The reaction proceeded smoothly under redox-neutral and mild conditions, leading to a divergent synthesis of α-cyanomethylaminoamides, α-acyloxyamides and α-acylaminoamides. In… read more here.
Keywords: divergent synthesis; aza cyclobutanone; cleavage; oxime esters ... See more keywords
NBS-induced intramolecular annulation reactions for the divergent synthesis of fused- and spirocyclic indolines.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01920a
Abstract: An NBS-induced intramolecular annulation of 3-(1H-indol-3-yl)-N-alkoxypropanamide is described. The reactions proceed well and quickly under mild conditions with the help of a base. It was found that C2-substituents on the indole ring in 3-(1H-indol-3-yl)-N-alkoxypropanamide have… read more here.
Keywords: nbs induced; intramolecular annulation; induced intramolecular; divergent synthesis ... See more keywords
Divergent Synthesis of Substituted Amino-1,2,4-triazole Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Synthesis"
DOI: 10.1055/a-1477-4630
Abstract: A divergent efficient assembly of disubstituted 1,2,4-triazoles was established by cyclization of readily accessible N′-nitro-2-hydrocarbylidene-hydrazinecarboximidamides with moderate to excellent yields under mild reaction conditions. This divergent synthetic strategy was achieved simply by varying the reaction… read more here.
Keywords: amino triazole; substituted amino; synthesis substituted; synthesis ... See more keywords