Divergent total syntheses of pseudoberberine and nitidine through C H vinylation and switchable 6π electrocyclizations
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.152839
Abstract: Abstract Quaternary protoberberine alkaloids and quaternary benzophenanthridine alkaloids are two biosynthetically related natural product families of biological importance. Although significant advances have been achieved in the synthetic chemistry of these alkaloids, a unified approach to… read more here.
Keywords: divergent total; total syntheses; vinylation switchable; pseudoberberine nitidine ... See more keywords
Asymmetric Divergent Total Syntheses of (+)-Decursivine and (+)- Serotobenine via Intramolecular Fischer Indole Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00848
Abstract: A new asymmetric synthetic route to (+)-decursivine and (+)-serotobenine is formulated. The key developments are the de novo construction of the crucial eight-membered 3,4-fused tricyclic indole ring engaged by the intramolecular Fischer indole synthesis and… read more here.
Keywords: indole synthesis; intramolecular fischer; asymmetric divergent; divergent total ... See more keywords
Divergent Total Syntheses of Hetero-Oligomeric Iridoid Glycosides.
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DOI: 10.1021/acs.orglett.2c03965
Abstract: Divergent total syntheses of the hetero-oligomeric iridoid glycosides mainly found in Dipsacus asper were achieved. Thus, loganin (1), which is important as a monomer unit, was efficiently synthesized by stereoselective reductive cyclization using secologanin (2)… read more here.
Keywords: syntheses hetero; divergent total; total syntheses; iridoid glycosides ... See more keywords
Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc00933g
Abstract: Concise, divergent total syntheses of five bioactive illudalane sesquiterpenes have been achieved. Our synthesis features an intermolecular [2+2+2] cycloaddition, and a lactone-directed aromatic C-H oxygenation to generate a temporary phenolic hydroxyl group which enables regioselective… read more here.
Keywords: total syntheses; syntheses five; divergent total; illudalane sesquiterpenes ... See more keywords