Divergent Transcription of the Nkx2-5 Locus Generates Two Enhancer RNAs with Opposing Functions
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DOI: 10.1016/j.isci.2020.101539
Abstract: Summary Enhancer RNAs (eRNAs) are a subset of long noncoding RNA generated from genomic enhancers: they are thought to act as potent promoters of the expression of nearby genes through interaction with the transcriptional and… read more here.
Keywords: divergent transcription; transcription; enhancer rnas; transcription nkx2 ... See more keywords
RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription
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DOI: 10.26508/lsa.202201394
Abstract: We show that the chromatin remodelling complex RSC and general regulatory factors (GRFs) limit transcription in the noncoding divergent direction, thereby increasing the directionality of promoters. The directionality of gene promoters—the ratio of protein-coding over… read more here.
Keywords: divergent transcription; transcription; promoter directionality; directionality ... See more keywords