Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02372-6
Abstract: To better define roles that astrocytes and microglia play in Alzheimer’s disease (AD), we used single-nuclei RNA-sequencing to comprehensively characterise transcriptomes in astrocyte and microglia nuclei selectively enriched during isolation post-mortem from neuropathologically defined AD… read more here.
Keywords: microglial transcriptional; diverse human; astrocytes microglia; pathology ... See more keywords
A diverse human learning optimization algorithm
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Global Optimization"
DOI: 10.1007/s10898-016-0444-2
Abstract: Human Learning Optimization is a simple but efficient meta-heuristic algorithm in which three learning operators, i.e. the random learning operator, the individual learning operator, and the social learning operator, are developed to efficiently search the… read more here.
Keywords: algorithm; diverse human; optimization; human learning ... See more keywords
Analysis of polygenic risk score usage and performance in diverse human populations
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11112-0
Abstract: A historical tendency to use European ancestry samples hinders medical genetics research, including the use of polygenic scores, which are individual-level metrics of genetic risk. We analyze the first decade of polygenic scoring studies (2008–2017,… read more here.
Keywords: risk; european ancestry; diverse human; performance ... See more keywords
Diverse human and bat-like rotavirus G3 strains circulating in suburban Bangkok
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268465
Abstract: Although rotavirus vaccines are available in many parts of the world and are effective in reducing the overall incidence of rotavirus infection, it remains a major cause of diarrhea in less-developed countries. Among various rotavirus… read more here.
Keywords: human bat; like rotavirus; diverse human; bat like ... See more keywords