Adenosine triphosphate energy‐independently controls protein homeostasis with unique structure and diverse mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4079
Abstract: Proteins function in the crowded cellular environments with high salt concentrations, thus facing tremendous challenges of misfolding/aggregation which represents a pathological hallmark of aging and an increasing spectrum of human diseases. Recently, intrinsically disordered regions… read more here.
Keywords: aggregation; energy; protein homeostasis; diverse mechanisms ... See more keywords
Diverse mechanisms for endogenous regeneration and repair in mammalian organs
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DOI: 10.1038/s41586-018-0073-7
Abstract: Mammalian organs comprise an extraordinary diversity of cell and tissue types. Regenerative organs, such as the skin and gastrointestinal tract, use resident stem cells to maintain tissue function. Organs with a lower cellular turnover, such… read more here.
Keywords: mammalian organs; mechanisms endogenous; diverse mechanisms; endogenous regeneration ... See more keywords
Multiple ways to a dead end: diverse mechanisms by which ALS mutant genes induce cell death
Sign Up to like & getrecommendations! Published in 2021 at "Cell Cycle"
DOI: 10.1080/15384101.2021.1886661
Abstract: ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a deadly neuromuscular disorder caused by progressive motor neuron loss in the brain and spinal cord. Over the past decades, a number of genetic mutations have been identified that… read more here.
Keywords: diverse mechanisms; als mutant; ways dead; dead end ... See more keywords
Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2018.1509609
Abstract: ABSTRACT In its third edition, the Vancouver Autophagy Symposium presented a platform for vibrant discussion on the differential roles of macroautophagy/autophagy in disease. This one-day symposium was held at the BC Cancer Research Centre in… read more here.
Keywords: autophagy dysregulation; mechanisms autophagy; disease; autophagy ... See more keywords
Keeping crispr in check: diverse mechanisms of phage-encoded anti-crisprs
Sign Up to like & getrecommendations! Published in 2019 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnz098
Abstract: ABSTRACT CRISPR-Cas represents the only adaptive immune system of prokaryotes known to date. These immune systems are widespread among bacteria and archaea, and provide protection against invasion of mobile genetic elements, such as bacteriophages and… read more here.
Keywords: crispr; crispr check; acr proteins; check diverse ... See more keywords
The diverse mechanisms and anticancer potential of naphthoquinones
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0925-8
Abstract: Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy is the… read more here.
Keywords: diverse mechanisms; mechanisms anticancer; potential naphthoquinones; cancer ... See more keywords
Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.824788
Abstract: The gram-positive bacterium Streptococcus pneumoniae is a leading cause of pneumonia, otitis media, septicemia, and meningitis in children and adults. Current prevention and treatment efforts are primarily pneumococcal conjugate vaccines that target the bacterial capsule… read more here.
Keywords: protective anti; diverse mechanisms; mechanisms protective; anti pneumococcal ... See more keywords
PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.624112
Abstract: The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, is one of the most extensively studied ligand-inducible transcription factors. Since its identification in the early 1990s, PPARγ is best known for its… read more here.
Keywords: ppar; diverse mechanisms; unified diverse; cancer ... See more keywords