Late Stage Lead Diversification (LSLD) Coupled with Quantitative NMR Spectroscopy to Identify New SAR Vectors at Nanomole Scale Synthesis: Application to Loratadine a Human Histamine H1 Receptor Inverse Agonist.
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DOI: 10.1021/acs.jmedchem.0c00483
Abstract: An experimental approach is described for late stage lead diversification (LSLD) of frontrunner drug candidates using nanomole scale amounts of lead compounds for SAR development. The process utilizes C-H bond activation methods to explore chemical… read more here.
Keywords: late stage; diversification lsld; lead diversification; stage lead ... See more keywords