Three Principles of Diversity-Generating Biosynthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.7b00330
Abstract: Natural products are significant therapeutic agents and valuable drug leads. This is likely owing to their three-dimensional structural complexity, which enables them to form complex interactions with biological targets. Enzymes from natural product biosynthetic pathways… read more here.
Keywords: biosynthesis; principles diversity; natural products; diversity generating ... See more keywords
Mechanisms and consequences of diversity-generating immune strategies
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2017.78
Abstract: Species from all five kingdoms of life have evolved sophisticated mechanisms to generate diversity in genes that are involved in host–pathogen interactions, conferring reduced levels of parasitism to both individuals and populations. Here, we highlight… read more here.
Keywords: diversity; immune strategies; mechanisms consequences; consequences diversity ... See more keywords
Determinants of adenine-mutagenesis in diversity-generating retroelements
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1240
Abstract: Abstract Diversity-generating retroelements (DGRs) vary protein sequences to the greatest extent known in the natural world. These elements are encoded by constituents of the human microbiome and the microbial ‘dark matter’. Variation occurs through adenine-mutagenesis,… read more here.
Keywords: mutagenesis; generating retroelements; adenine mutagenesis; diversity generating ... See more keywords
A diversity-generating retroelement encoded by a globally ubiquitous Bacteroides phage
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DOI: 10.1186/s40168-018-0573-6
Abstract: BackgroundDiversity-generating retroelements (DGRs) are genetic cassettes that selectively mutate target genes to produce hypervariable proteins. First characterized in Bordetella bacteriophage BPP-1, the DGR creates a hypervariable phage tail fiber that enables host tropism switching. Subsequent… read more here.
Keywords: retroelement encoded; phage; generating retroelement; encoded globally ... See more keywords
Crystal structure of a Thermus aquaticus diversity-generating retroelement variable protein
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DOI: 10.1371/journal.pone.0205618
Abstract: Diversity-generating retroelements (DGRs) are widely distributed in bacteria, archaea, and microbial viruses, and bring about unparalleled levels of sequence variation in target proteins. While DGR variable proteins share low sequence identity, the structures of several… read more here.
Keywords: diversity generating; variable protein; aquaticus; dgr ... See more keywords