Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?
Sign Up to like & getrecommendations! Published in 2018 at "Trends in microbiology"
DOI: 10.1016/j.tim.2018.08.002
Abstract: The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to contrast the genetic landscape in… read more here.
Keywords: laboratory strains; strains limit; diversity homogeneous; limit discovery ... See more keywords
Emergence of diversity in homogeneous coupled Boolean networks.
Sign Up to like & getrecommendations! Published in 2018 at "Physical Review E"
DOI: 10.1103/physreve.97.052415
Abstract: The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks… read more here.
Keywords: diversity homogeneous; emergence diversity; biology; boolean networks ... See more keywords