IMCR coupled one-pot process: Efficient tools to Diversity-Oriented Synthesis of structural peptidomimetics containing heterocyclic bioisosteres and DFT conformational studies.
Sign Up to like & getrecommendations! Published in 2024 at "ChemPlusChem"
DOI: 10.1002/cplu.202300633
Abstract: Multicomponent diversity-oriented synthesis (DOS) of conformationally anchored structural peptidomimetics like 2,5-diketopiperazines (2,5-DKP) containing heterocyclic bioisosteres of the amide bond, such as 1,2,3-triazoles and 1,5-disubstituted tetrazoles (1,5-DS-T) is described. Structural peptidomimetics are synthesized from similar available starting… read more here.
Keywords: diversity oriented; structural peptidomimetics; heterocyclic bioisosteres; oriented synthesis ... See more keywords
Diversity-Oriented Metal-Free Synthesis of Nitrogen-Containing Heterocycles Using Atropaldehyde Acetals as a Dual C3/C2-Synthon.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202201301
Abstract: A highly efficient and elegant diversity-oriented reaction paradigm employing atropaldehyde acetals as a novel dual C2/C3 synthon was developed under metal-free conditions using glycine esters as the counter-part reagents, which allowed rapid synthesis of two… read more here.
Keywords: dual synthon; nitrogen containing; metal free; synthesis ... See more keywords
Diversity‐Oriented Synthesis of Carbohydrate Scaffolds through the Prins Cyclization of Differently Protected d‐Mannitol‐Derived Homoallylic Alcohols
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201701172
Abstract: A diversity oriented synthesis of a variety of carbohydrate scaffolds such as sugar fused isochroman derivatives, bicyclic vinyl halide derivatives, fluorine substituted tetrahydropyrans, and a furan derivative is reported. This has been achieved by using… read more here.
Keywords: diversity oriented; carbohydrate scaffolds; derived homoallylic; homoallylic alcohols ... See more keywords
Recent Advances in Diversity-Oriented Polymerization Using Cu-Catalyzed Multicomponent Reactions.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202100642
Abstract: Diversification of polymer structures is important for imparting various properties and functions to polymers, so as to realize novel applications of these polymers. In this regard, diversity-oriented polymerization (DOP) is a powerful synthetic strategy for… read more here.
Keywords: polymerization; advances diversity; diversity oriented; recent advances ... See more keywords
Diversity-Oriented Synthesis of Fluoromethylated Arenes via Palladium-Catalyzed C-H Fluoromethylation of Aryl Iodides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04367
Abstract: Herein we report the first versatile and expeditious method for the site-selective C-H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of fluoromethylated… read more here.
Keywords: oriented synthesis; aryl iodides; fluoromethylated arenes; diversity oriented ... See more keywords
Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01239
Abstract: The diversity of cyclic peptides was expanded by elaborating Mitsunobu macrocyclization, tethering various hydroxy acid building blocks with different Nε-amine substituents. This new strategy was then applied in synthesizing peptidomimetic estrogen receptor modulator (PERM) analogs… read more here.
Keywords: oriented synthesis; diversity; mitsunobu macrocyclization; diversity oriented ... See more keywords
Diversity-Oriented Synthesis of Glycosylphosphatidylinositol Probes Based on an Orthogonally Protected Pentasaccharide.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00448
Abstract: Two glycosylphosphatidylinositol (GPI) derivatives having an alkynyl group at different positions were derived from the same orthogonally protected pentasaccharide that in turn was assembled by a convergent [3+2] glycosylation strategy. The resultant alkynylated GPIs are… read more here.
Keywords: synthesis glycosylphosphatidylinositol; orthogonally protected; oriented synthesis; diversity oriented ... See more keywords
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.
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DOI: 10.1021/acsinfecdis.6b00206
Abstract: In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of… read more here.
Keywords: oriented synthesis; clostridium difficile; diversity oriented; identification highly ... See more keywords
Diversity-Oriented Approaches toward the Synthesis of Cyclophanes
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DOI: 10.1021/acsomega.9b00467
Abstract: Here, we describe synthetic approaches to a variety of cyclophanes involving transition-metal-catalyzed reactions such as the Suzuki–Miyaura cross-coupling, olefin metathesis, enyne metathesis, Glaser–Eglinton coupling, Yamamoto coupling, etc. On several occasions, alkylation, benzylation, Grignard reagents, and… read more here.
Keywords: chemistry; diversity oriented; synthesis cyclophanes; approaches toward ... See more keywords
Step-Economical Photoassisted Diversity-Oriented Synthesis: Sustaining Cascade Photoreactions in Oxalyl Anilides to Access Complex Polyheterocyclic Molecular Architectures.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07598
Abstract: Atom- and step-economy in photoassisted diversity-oriented synthesis (DOS) is achieved with a versatile oxalyl linker offering rapid access to complex alkaloid mimics in very few experimentally simple steps: (i) it allows for fast tethering of… read more here.
Keywords: photoassisted diversity; diversity oriented; molecular architectures; access complex ... See more keywords
Diversity-oriented synthesis of imidazo[2,1-a]isoquinolines.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc05390a
Abstract: Herein, we report an efficient and practical strategy for the synthesis of five types of imidazo[2,1-a]isoquinolines via Cp*RhIII-catalyzed [4+2] annulation of 2-arylimidazoles and α-diazoketoesters, whose structural and substituted diversity at 5- or 6-position can be… read more here.
Keywords: diversity oriented; imidazo isoquinolines; oriented synthesis; synthesis imidazo ... See more keywords