Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23649-0
Abstract: Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here,… read more here.
Keywords: diversity outbred; genetics; bmd; outbred mice ... See more keywords
High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains.
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsz278
Abstract: STUDY OBJECTIVES This study describes high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of robustness, reliability, and heritability among Diversity Outbred (DO) mice and their eight founder strains. METHODS We performed… read more here.
Keywords: founder; diversity outbred; founder strains; outbred mice ... See more keywords
Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001571
Abstract: Identification of genetic variants that influence susceptibility to pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with persistent pain, we… read more here.
Keywords: response; diversity outbred; formalin; late phase ... See more keywords
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0242665
Abstract: Sex-specific transcription characterizes hundreds of genes in mouse liver, many implicated in sex-differential drug and lipid metabolism and disease susceptibility. While the regulation of liver sex differences by growth hormone-activated STAT5 is well established, little… read more here.
Keywords: diversity outbred; genetic factors; sex specific; sex ... See more keywords
Intramembranous bone regeneration in diversity outbred mice is heritable.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.2139/ssrn.4117253
Abstract: There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as bone mineral density have been… read more here.
Keywords: diversity outbred; bone; bone regeneration; intramembranous bone ... See more keywords