Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23649-0
Abstract: Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here,… read more here.
Keywords: diversity outbred; genetics; bmd; outbred mice ... See more keywords
High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains.
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsz278
Abstract: STUDY OBJECTIVES This study describes high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of robustness, reliability, and heritability among Diversity Outbred (DO) mice and their eight founder strains. METHODS We performed… read more here.
Keywords: founder; diversity outbred; founder strains; outbred mice ... See more keywords
Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001571
Abstract: Identification of genetic variants that influence susceptibility to pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with persistent pain, we… read more here.
Keywords: response; diversity outbred; formalin; late phase ... See more keywords
Abstract 114: Identification of the actionable target, LILRB4, through genetic linkage analysis of Diversity Outbred (DO) F1 mice expressing HER2(neu)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-114
Abstract: Our goal is to identify, in situ, the regulatory genes that dictate the onset age and growth rate of spontaneously arising tumors to implement new intervention strategies. For genetic linkage analysis, we crossed HER2(neu) Tg… read more here.
Keywords: cancer; genetic linkage; linkage analysis; tumor ... See more keywords
Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811241269691
Abstract: Background: Nicotine is largely responsible for the initiation and maintenance of tobacco dependence and contributes to a global health problem. Aims: This study characterizes nicotine oral consumption and preference in male and female mice of… read more here.
Keywords: consumption; preference; nicotine; nicotine consumption ... See more keywords
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0242665
Abstract: Sex-specific transcription characterizes hundreds of genes in mouse liver, many implicated in sex-differential drug and lipid metabolism and disease susceptibility. While the regulation of liver sex differences by growth hormone-activated STAT5 is well established, little… read more here.
Keywords: diversity outbred; genetic factors; sex specific; sex ... See more keywords
Intramembranous bone regeneration in diversity outbred mice is heritable.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.2139/ssrn.4117253
Abstract: There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as bone mineral density have been… read more here.
Keywords: diversity outbred; bone; bone regeneration; intramembranous bone ... See more keywords
Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes
Sign Up to like & getrecommendations! Published in 2024 at "Vaccines"
DOI: 10.3390/vaccines12030266
Abstract: Group B coxsackieviruses (CVBs) cause a wide range of diseases in humans, but no vaccines are currently available to prevent these infections. Previously, we had demonstrated that a live attenuated CVB3 vaccine virus, Mutant 10… read more here.
Keywords: virus; cvb3 infection; diversity outbred; mt10 vaccine ... See more keywords