Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
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DOI: 10.1038/ncomms14545
Abstract: How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of… read more here.
Keywords: tissue organization; somatic mutations; divisional load; tissue ... See more keywords