Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway.
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DOI: 10.1016/j.lfs.2017.08.035
Abstract: AIMS Hypothalamic obesity is a severe condition without any effective therapy. Bariatric operations appear as an alternative treatment, but the effects of this procedure are controversial. We, herein, investigated the effects of duodeno-jejunal bypass (DJB)… read more here.
Keywords: hyo rats; hyo; duodeno jejunal; hypothalamic obese ... See more keywords
Effects of duodenal–jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats
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DOI: 10.2147/dmso.s190631
Abstract: Background Duodenal–jejunal bypass (DJB) is an important component of many types of current bariatric surgery including Roux-en-Y gastric bypass, mini-gastric bypass, biliopancreatic diversion, duodenal switch, and DJB plus sleeve gastrectomy. Surgery is often observed to… read more here.
Keywords: jejunal bypass; bypass; djb; surgery ... See more keywords
Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy
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DOI: 10.3389/fendo.2019.00566
Abstract: Objective: Bariatric surgery can profoundly improve glucose and lipid metabolism in diabetic rats. Fibroblast growth factor 21 (FGF21) is an important hormone with multiple metabolic beneficial effects. Alteration in serum FGF21 level after bariatric surgery… read more here.
Keywords: fat diet; sensitivity; fgf21; high fat ... See more keywords
Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway
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DOI: 10.3748/wjg.v28.i31.4328
Abstract: BACKGROUND Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass (DJB). Serum bile acids are elevated postoperatively. However, the clinical relevance is not known. Bile acids in the… read more here.
Keywords: luminal bile; bile acids; djb; bile ... See more keywords
Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats
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DOI: 10.3748/wjg.v28.i31.4338
Abstract: BACKGROUND The mechanisms underlying diabetes remission after duodenal-jejunal bypass (DJB) remain elusive. In DJB surgery, the duodenum is excluded. However, the duodenum has emerged as an important regulator of glucose homeostasis, and elevated duodenal SIRT1… read more here.
Keywords: expression; sirt1 expression; group; djb ... See more keywords