DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Cancer"
DOI: 10.1038/s41416-019-0695-z
Abstract: Background Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. Methods Tissue microarrays (TAMs) including 411 cases of CRC tissues and… read more here.
Keywords: hif transcription; dkc1; colorectal cancer; dkc1 expression ... See more keywords
DKC1-mediated pseudouridylation of rRNA targets hnRNP A1 to sustain IRES-dependent translation and ATF4-driven metabolic adaptation
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DOI: 10.1126/sciadv.adv9401
Abstract: The pseudouridine synthase DKC1 regulates internal ribosome entry site (IRES)–dependent translation and is up-regulated in cancers by the MYC family of oncogenes. The functional significance of DKC1 up-regulation and the mechanistic connection between pseudouridylation and… read more here.
Keywords: ires dependent; dependent translation; pseudouridylation; dkc1 ... See more keywords
DKC1 serves as a potential prognostic biomarker for human clear cell renal cell carcinoma and promotes its proliferation, migration and invasion via the NF‑κB pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6484
Abstract: DKC1, an X‑linked gene encoding dyskerin at Xq28, is a crucial component of the telomerase complex and is indispensable for normal telomere function and the post‑-transcriptional modification of precursor rRNA. It has been revealed to… read more here.
Keywords: ccrcc; dkc1; expression; dkc1 expression ... See more keywords