Platelet‐rich plasma inhibits Wnt/&bgr;‐catenin signaling in rabbit cartilage cells activated by IL‐1&bgr;
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.12.031
Abstract: Objective: Platelet‐rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/&bgr;‐catenin signaling in rabbit chondrocytes. Methods: Using 3‐month‐old New Zealand… read more here.
Keywords: bgr catenin; bgr; wnt bgr; prp ... See more keywords
The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma?
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2016.08.014
Abstract: BACKGROUND Dickkopf-1 (Dkk-1) is a soluble inhibitor of the canonical Wnt pathway, which plays critical roles in embryonic development. Evidence suggests that this molecule regulates several aspects of both bone biology and fibrosis. OBJECTIVES To… read more here.
Keywords: fibrosis; remodeling fibrosis; role; joint remodeling ... See more keywords
Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
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DOI: 10.1038/s41598-017-01119-2
Abstract: Aberrant activation of the Wnt/β-catenin signaling pathway plays a pathogenic role in retinal inflammation and neovascularization. Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a specific inhibitor of this pathway, are altered in patients… read more here.
Keywords: exudative amd; levels dickkopf; patients exudative; amd ... See more keywords
The possible role of Dickkopf-1, Golgi protein- 73 and Midkine as predictors of hepatocarcinogenesis: a review and an Egyptian study
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DOI: 10.1038/s41598-020-62051-6
Abstract: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible… read more here.
Keywords: golgi protein; mdk; possible role; mdk dkk ... See more keywords
Economic benefits of remimazolam compared to midazolam and propofol for procedural sedation in colonoscopies and bronchoscopies
Sign Up to like & getrecommendations! Published in 2023 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2023.2196198
Abstract: Abstract Background Sedation is common practice in endoscopic procedures to suppress a patient’s level of consciousness while maintaining the cardio-respiratory function. Midazolam and propofol are the sedatives most frequently used for procedural sedation at hospitals… read more here.
Keywords: midazolam propofol; midazolam; cost; dkk ... See more keywords
Bone morphogenetic proteins and Dickkopf-1 in ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Rheumatology"
DOI: 10.1080/03009742.2017.1287305
Abstract: Objectives: To determine bone morphogenetic proteins (BMPs) and Dickkopf homologue-1 (Dkk-1) levels in ankylosing spondylitis (AS). Method: Serum BMPs and Dkk-1 were measured in 72 AS patients and 30 healthy controls. For AS patients, we… read more here.
Keywords: ankylosing spondylitis; morphogenetic proteins; disease; bone morphogenetic ... See more keywords
The role of Dickkopf-1 as a potential prognostic marker in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1356510
Abstract: ABSTRACT Dickkopf-1(DKK-1), the downstream target of β-catenin/T-cell factor, participates in a negative feedback loop in the Wnt signaling and reported as an important biomarker in many tumors. In this study, we analyzed the expression of… read more here.
Keywords: pdac; expression; pancreatic ductal; ductal adenocarcinoma ... See more keywords
FRI0485 In peripheral psoriatic arthritis DKK-1 and pth are lower than in rheumatoid arthritis and healthy controls
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.2728
Abstract: Background The recent characterization of the canonical WNT pathway in the regulation of bone modeling and remodeling provided important insights for our understanding of the pathophysiology of bone involvement in chronic arthritis [1]. Dkk-1 and… read more here.
Keywords: pth; group; bone; rheumatoid arthritis ... See more keywords
THU0404 DICKKOPF-1 SERUM LEVELS AND THEIR CORRELATION WITH ACTIVE AND CHRONIC MRI-CHANGES OF SACROILIAC JOINTS AND CLINICAL INDICES IN PATIENTS WITH SPONDYLOARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3976
Abstract: Background The lack of valid biochemical markers for spondyloarthritis (SpA) patients requires searching the additional options to increase sensitivity of clinical and radiological methods in validation of changes in sacroiliac joints (SIJ). The molecular basis… read more here.
Keywords: spa patients; serum; serum levels; mri ... See more keywords
The Increasing Level of DKK-1 as a New Bone Formation Factor in Patients with Early Spondyloarthritis
Sign Up to like & getrecommendations! Published in 2023 at "Autoimmune Diseases"
DOI: 10.1155/2023/5543234
Abstract: The role of dickkopf-related protein 1 (DKK-1) in radiographic development may become a robust marker for early spondyloarthritis (SpA) diagnosis. This study aimed at determining the serum DKK-1 profile in patients with SpA and investigating… read more here.
Keywords: disease; disease duration; spa; serum dkk ... See more keywords
Decreased Serum Dickkopf-1 Levels After Hypoglycemic Therapy in Patients with Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s376988
Abstract: Aim Dickkopf-1 (DKK-1) is a major inhibitor of Wingless protein signaling pathway, which is involved in glucose metabolism and cardiovascular diseases. The aim of the study was to investigate the changes of serum DKK-1 levels… read more here.
Keywords: patients type; baseline dkk; dkk; levels hypoglycemic ... See more keywords