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   Articles with "dkk1" as a keyword



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Dkk1 inhibits malignant transformation induced by Bmi1 via the β‐catenin signaling axis in WB‐F344 oval cells

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recommendations! Published in 2021 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13132

Abstract: Dickkopf‐1 (Dkk1) is an inhibitor of Wnt signaling involved in cancer cell proliferation, apoptosis, and migration and angiogenesis. It was previously reported that B cell‐specific Moloney mouse leukemia virus integration site 1 (Bmi1) activates the… read more here.

Keywords: induced bmi1; dkk1; f344 oval; oval cells ... See more keywords
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DKK1 promotes NUAK1 transcriptional expression through the activation Akt in hepatocellular carcinoma

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11974

Abstract: NUAK1 is a serine/threonine kinase that has been shown to be associated with poor prognosis in several cancers. Although NUAK1 is frequently overexpressed at the transcript level in hepatocellular carcinoma (HCC), the actual role of… read more here.

Keywords: hepatocellular carcinoma; nuak1 expression; hcc; expression ... See more keywords
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Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation

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recommendations! Published in 2017 at "Calcified Tissue International"

DOI: 10.1007/s00223-017-0338-4

Abstract: Wnt antagonist Dkk1 is a negative regulator of bone formation and Dkk1+/− heterozygous mice display a high bone mass phenotype. Complete loss of Dkk1 function disrupts embryonic head development. Homozygous Dkk1−/− mice that were heterozygous… read more here.

Keywords: phenotype; bone formation; dkk1; bone ... See more keywords
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Computationally Design of Inhibitory Peptides Against Wnt Signaling Pathway: In Silico Insight on Complex of DKK1 and LRP6

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recommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"

DOI: 10.1007/s10989-017-9589-1

Abstract: Wnt signaling pathway plays a major role in the regulation of cell proliferation, migration, tissue homeostasis, tumor progression and cancer. This pathway can be antagonized by different proteins such as DKK proteins, which disrupt the… read more here.

Keywords: wnt signaling; dkk1; design inhibitory; lrp6 ... See more keywords
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DKK1 and sclerostin are early markers of relapse in multiple myeloma.

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recommendations! Published in 2018 at "Bone"

DOI: 10.1016/j.bone.2017.10.004

Abstract: Recent studies have shown that Dickkopf-related protein (DKK1) and sclerostin decrease when a complete response (CR) is obtained after chemotherapy in myeloma multiple (MM). To study variations in DKK1, sclerostin and P1NP in patients treated… read more here.

Keywords: dkk1 sclerostin; myeloma; dkk1; early markers ... See more keywords
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Silencing GSK3β instead of DKK1 can inhibit osteogenic differentiation caused by co-exposure to fluoride and arsenic.

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recommendations! Published in 2019 at "Bone"

DOI: 10.1016/j.bone.2019.03.016

Abstract: Chronic exposure to combined fluoride (F) and arsenic (As) continues to be a major public health problem worldwide, attracting the attention of an increasing number of researchers. While bone is the main target organ of… read more here.

Keywords: catenin; dkk1; osteogenic differentiation; fluoride arsenic ... See more keywords
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Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms

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recommendations! Published in 2017 at "Nature Medicine"

DOI: 10.1038/nm.4251

Abstract: The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known… read more here.

Keywords: hematopoietic regeneration; recovery; dkk1; regeneration ... See more keywords
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Dickkopf-1 directs periosteal bone formation in two murine models of inflammatory arthritis

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recommendations! Published in 2022 at "Scandinavian Journal of Rheumatology"

DOI: 10.1080/03009742.2022.2040136

Abstract: Objective The Wnt signalling antagonist Dickkopf-1 (DKK1) inhibits osteoblast differentiation and function and has been described to play a central role in promoting bone loss, while blockade of DKK1 increases bone formation. We investigated the… read more here.

Keywords: bone formation; new bone; arthritis; formation ... See more keywords
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LncRNA XIST facilitates cell growth, migration and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma

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recommendations! Published in 2019 at "Cell Cycle"

DOI: 10.1080/15384101.2019.1632134

Abstract: ABSTRACT Long non-coding RNAs (lncRNAs) have been confirmed to be aberrantly expressed and involved in the progression of neuroblastoma. This study aimed to explore the expression profile of lncRNA X-inactive specific transcript (XIST) and its… read more here.

Keywords: xist; invasion; dkk1; neuroblastoma ... See more keywords
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Consequences of endogenous and exogenous WNT signaling for development of the preimplantation bovine embryo†

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recommendations! Published in 2017 at "Biology of Reproduction"

DOI: 10.1093/biolre/iox048

Abstract: Abstract The specific role of WNT signaling during preimplantation development remains unclear. Here, we evaluated consequences of activation and inhibition of β-catenin (CTNNB1)-dependent and -independent WNT signaling in the bovine preimplantation embryo. Activation of CTNNB1-mediated… read more here.

Keywords: wnt signaling; dkk1; preimplantation; embryo ... See more keywords
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Andrographis overcomes 5-fluorouracil associated chemoresistance through inhibition of DKK1 in colorectal cancer.

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recommendations! Published in 2021 at "Carcinogenesis"

DOI: 10.1093/carcin/bgab027

Abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related deaths in the US. 5-fluorouracil (5FU)-based chemotherapeutic drug remains a mainstay of CRC treatment. Unfortunately, ~50-60% of patients eventually develop resistance to 5FU, leading… read more here.

Keywords: dkk1; colorectal cancer; resistance; andrographis ... See more keywords