Study on the role of MYCN in retinoblastoma by inhibiting p53 and activating wnt/βcatenin/Fra‐1 signaling pathway by reducing DKK3
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22222
Abstract: Retinoblastoma (RB) is a pediatric malignancy, typically diagnosed at birth or during early childhood. The pathogenesis of RB is marked by the amplification of the Basic Helix–Loop–Helix (BHLH) Transcription Factor MYCN, which serves as a… read more here.
Keywords: mycn; catenin fra; dkk3; cell ... See more keywords
Down-regulation of MDR1 by Ad-DKK3 via Akt/NFκB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2894-5
Abstract: BackgroundGlioblastoma multiforme (GBM) is the most malignant of brain tumors. Acquired drug resistance is a major obstacle for successful treatment. Earlier studies reported that expression of the multiple drug resistance gene (MDR1) is regulated by… read more here.
Keywords: akt; augments anti; dkk3; anti tumor ... See more keywords
Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.312945
Abstract: Rationale: Vascular progenitor cells play key roles in physiological and pathological vascular remodeling—a process that is crucial for the regeneration of acellular biodegradable scaffolds engineered as vital strategies against the limited availability of healthy autologous… read more here.
Keywords: vascular progenitor; dkk3; migration; progenitor ... See more keywords
Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321744
Abstract: Background: Dkk3 (Dickkopf-3) is a secreted glycoprotein known for its proapoptotic and angiogenic activity. The role of Dkk3 in cardiovascular homeostasis is largely unknown. Remarkably, the Dkk3 gene maps within a chromosome segment linked to… read more here.
Keywords: role; dkk3; expression; stroke ... See more keywords
DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01794-5
Abstract: Background Intracerebral hemorrhage (ICH) is the most devastating stroke subtype, with a poor prognosis and few proven treatments. Neuroinflammation is associated with ICH-induced brain injury and unfavorable outcomes. There is growing evidence that Dickkopf (DKK)… read more here.
Keywords: kremen dvl; intracerebral hemorrhage; following intracerebral; dkk3 ... See more keywords
The Dkk3 gene encodes a vital intracellular regulator of cell proliferation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0181724
Abstract: Members of the Dickkopf (Dkk) family of Wnt antagonists interrupt Wnt-induced receptor assembly and participate in axial patterning and cell fate determination. One family member, DKK3, does not block Wnt receptor activation. Loss of Dkk3… read more here.
Keywords: cell proliferation; catenin; dkk3; gene ... See more keywords
miR-25-3p protects renal tubular epithelial cells from apoptosis induced by renal IRI by targeting DKK3
Sign Up to like & getrecommendations! Published in 2021 at "Open Life Sciences"
DOI: 10.1515/biol-2021-0127
Abstract: Abstract Renal ischemia-reperfusion injury (IRI) is one of the main causes of acute kidney injury (AKI). So far, there have been many studies on renal IRI, although an effective treatment method has not been developed.… read more here.
Keywords: mir protects; dkk3; mir; apoptosis ... See more keywords
WIF1 and DKK3 in prostate cancer: from molecular pathways to therapeutic targets: a narrative review
Sign Up to like & getrecommendations! Published in 2024 at "Translational Andrology and Urology"
DOI: 10.21037/tau-24-304
Abstract: Background and Objective Prostate cancer is a major cause of cancer-related morbidity and mortality in men globally. The pathogenesis involves complex interactions between genetic mutations and environmental factors, activating multiple signaling pathways, especially Wnt/β-catenin, PI3K/Akt,… read more here.
Keywords: dkk3; cancer; wif1 dkk3; prostate cancer ... See more keywords
Serum Dickkopf-3 as a biomarker for predicting acute kidney injury in postoperative intensive care patients.
Sign Up to like & getrecommendations! Published in 2025 at "Minerva anestesiologica"
DOI: 10.23736/s0375-9393.24.18677-4
Abstract: BACKGROUND Acute kidney injury (AKI) is a common and significant complication in the Intensive Care Unit (ICU), affecting more than half of all patients admitted. This condition is associated with increased morbidity and mortality, underscoring… read more here.
Keywords: serum dkk3; dkk3; kidney injury; acute kidney ... See more keywords
Apogossypolone Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating DKK3
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.948023
Abstract: Apogossypolone (ApoG2), a novel derivative of gossypol lacking of two aldehyde groups, exhibits anti-tumor effects. However, the mechanisms by which ApoG2 regulates cervical cancer (CC) cells remain unclear. In this study, we treated two CC… read more here.
Keywords: cervical cancer; cell; cell proliferation; dkk3 ... See more keywords
Dickkopf-3: Current Knowledge in Kidney Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.533344
Abstract: Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney… read more here.
Keywords: dickkopf current; kidney; kidney diseases; dkk3 ... See more keywords