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   Articles with "dko" as a keyword



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PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-114891

Abstract: Hematopoietic stem cells (HSCs) are a rare population in the bone marrow (BM) that mostly exists in a quiescent state. Upon environmental stresses such as infection, inflammatory signals are released and induce HSCs to proliferate… read more here.

Keywords: dko; p110; il1 tnf; p110 p110 ... See more keywords
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Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

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recommendations! Published in 2018 at "Endocrinology"

DOI: 10.1210/en.2018-00040

Abstract: Proper regulation of energy metabolism requires neurons in the central nervous system to respond dynamically to signals that reflect the body's energy reserve, and one such signal is leptin. Agouti-related protein (AgRP) is a hypothalamic… read more here.

Keywords: hepatic lipid; dko; agouti related; energy ... See more keywords
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35-OR: Epigenetic Regulation of White Adipose Tissue Browning by HMGN Proteins

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recommendations! Published in 2021 at "Diabetes"

DOI: 10.2337/db21-35-or

Abstract: Chromatin architecture proteins HMGNs (High Mobility Group Nucleosome-binding) affect local and global chromatin structure and colocalize with cell-specific regulatory sites and regulate cell identity. The role of HMGN proteins in adipocyte function and energy metabolism… read more here.

Keywords: dko mice; dko; hmgn proteins; mice ... See more keywords
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Minocycline Inhibits Microglial Activation and Improves Visual Function in a Chronic Model of Age-Related Retinal Degeneration

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10123222

Abstract: Age-related macular degeneration (AMD) is a chronic disease, which progresses slowly from early to late stages over many years. Inflammation critically contributes to the pathogenesis of AMD. Here, we investigated the therapeutic potential of minocycline… read more here.

Keywords: visual function; microglial activation; dko; treatment ... See more keywords
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Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections.

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recommendations! Published in 2017 at "Journal of microbiology and biotechnology"

DOI: 10.4014/jmb.1704.04039

Abstract: Klebsiella pneumoniae is an opportunistic and clinically significant emerging pathogen. We investigated the relative roles of Toll-like receptor (TLR) 2 and TLR4 in initiating host defenses against K. pneumoniae. TLR2 knockout (KO), TLR4 KO, TLR2/4… read more here.

Keywords: toll like; dko; tlr2; like receptor ... See more keywords