Leucine rich repeat kinase knockout (LRRK KO) mouse model: Linking pathological hallmarks of inherited and sporadic Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27267
Abstract: Autosomal dominant mutations in Leucine Rich Repeat Kinase 2 (LRRK2) underlie the most common cause of familial Parkinson’s disease (PD) and have also been associated with sporadic cases. However, LRRK2 mutation knockin and LRRK2 knockout… read more here.
Keywords: dko mice; lrrk dko; lrrk; lrrk2 ... See more keywords
Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49140-x
Abstract: Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g. prednisolone) remain the only drugs with a favorable impact on DMD patients, but not… read more here.
Keywords: dko mice; treatment; pathology; prednisolone ... See more keywords
Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
Sign Up to like & getrecommendations! Published in 2021 at "Glycobiology"
DOI: 10.1093/glycob/cwab081
Abstract: Fractones, specialized extracellular matrix structures found in the subventricular zone (SVZ) neurogenic niche, can capture growth factors, such as basic fibroblast growth factor, from the extracellular milieu through a heparin-binding mechanism for neural stem cell… read more here.
Keywords: subventricular zone; dko mice; heparan sulfate; young aged ... See more keywords
P5‐26: Validity of PIRO‐score as an assessment tool for mortality risk of COVID‐19 pneumonia in World Citi Medical Center. A retrospective observational cohort study
Sign Up to like & getrecommendations! Published in 2021 at "Respirology"
DOI: 10.1111/resp.14150_233
Abstract: remains unclear due to the lack of culture methods and simple murine models of PCP. We have found that PCP spontaneously developed in mice lacking Caspase 8 and Ripk3 (DKO), both of these genes are… read more here.
Keywords: dko mice; piro score; score assessment; mice ... See more keywords
35-OR: Epigenetic Regulation of White Adipose Tissue Browning by HMGN Proteins
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-35-or
Abstract: Chromatin architecture proteins HMGNs (High Mobility Group Nucleosome-binding) affect local and global chromatin structure and colocalize with cell-specific regulatory sites and regulate cell identity. The role of HMGN proteins in adipocyte function and energy metabolism… read more here.
Keywords: dko mice; dko; hmgn proteins; mice ... See more keywords
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.586980
Abstract: Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up-regulation… read more here.
Keywords: dko mice; cholic acid; cholesterol; acid chenodeoxycholic ... See more keywords
Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00333
Abstract: The corticospinal tract (CST) plays an important role in controlling voluntary movement. Because the CST has a long trajectory throughout the brain toward the spinal cord, many axon guidance molecules are required to navigate the… read more here.
Keywords: dko mice; corticospinal tract; cst; mice ... See more keywords
Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020448
Abstract: Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. GclmKO knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; GclmKO… read more here.
Keywords: gsh; ascorbic acid; epileptic seizures; pathology ... See more keywords
Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043452
Abstract: Background Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability due to an insufficient TH transport and action in the CNS. As a therapeutic strategy, application of Triac (3, 5, 3’-triiodothyroacetic acid) and… read more here.
Keywords: ditpa; thyroid hormone; dko mice; mice ... See more keywords
Improved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11040247
Abstract: Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by a lack of dystrophin expression in the sarcolemma of muscle fibers. DMD patients acquire bone abnormalities including osteopenia, fragility fractures, and scoliosis indicating a… read more here.
Keywords: dko mice; improved bone; parabiosis; bone ... See more keywords