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Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27267
Abstract: Autosomal dominant mutations in Leucine Rich Repeat Kinase 2 (LRRK2) underlie the most common cause of familial Parkinson’s disease (PD) and have also been associated with sporadic cases. However, LRRK2 mutation knockin and LRRK2 knockout…
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Keywords:
dko mice;
lrrk dko;
lrrk;
lrrk2 ... See more keywords
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Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49140-x
Abstract: Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g. prednisolone) remain the only drugs with a favorable impact on DMD patients, but not…
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Keywords:
dko mice;
treatment;
pathology;
prednisolone ... See more keywords
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Published in 2021 at "Glycobiology"
DOI: 10.1093/glycob/cwab081
Abstract: Fractones, specialized extracellular matrix structures found in the subventricular zone (SVZ) neurogenic niche, can capture growth factors, such as basic fibroblast growth factor, from the extracellular milieu through a heparin-binding mechanism for neural stem cell…
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Keywords:
subventricular zone;
dko mice;
heparan sulfate;
young aged ... See more keywords
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Published in 2021 at "Respirology"
DOI: 10.1111/resp.14150_233
Abstract: remains unclear due to the lack of culture methods and simple murine models of PCP. We have found that PCP spontaneously developed in mice lacking Caspase 8 and Ripk3 (DKO), both of these genes are…
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Keywords:
dko mice;
piro score;
score assessment;
mice ... See more keywords
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Published in 2021 at "Diabetes"
DOI: 10.2337/db21-35-or
Abstract: Chromatin architecture proteins HMGNs (High Mobility Group Nucleosome-binding) affect local and global chromatin structure and colocalize with cell-specific regulatory sites and regulate cell identity. The role of HMGN proteins in adipocyte function and energy metabolism…
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Keywords:
dko mice;
dko;
hmgn proteins;
mice ... See more keywords
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Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.586980
Abstract: Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up-regulation…
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Keywords:
dko mice;
cholic acid;
cholesterol;
acid chenodeoxycholic ... See more keywords
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Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00333
Abstract: The corticospinal tract (CST) plays an important role in controlling voluntary movement. Because the CST has a long trajectory throughout the brain toward the spinal cord, many axon guidance molecules are required to navigate the…
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Keywords:
dko mice;
corticospinal tract;
cst;
mice ... See more keywords
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Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020448
Abstract: Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. GclmKO knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; GclmKO…
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Keywords:
gsh;
ascorbic acid;
epileptic seizures;
pathology ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043452
Abstract: Background Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability due to an insufficient TH transport and action in the CNS. As a therapeutic strategy, application of Triac (3, 5, 3’-triiodothyroacetic acid) and…
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Keywords:
ditpa;
thyroid hormone;
dko mice;
mice ... See more keywords
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Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11040247
Abstract: Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by a lack of dystrophin expression in the sarcolemma of muscle fibers. DMD patients acquire bone abnormalities including osteopenia, fragility fractures, and scoliosis indicating a…
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Keywords:
dko mice;
improved bone;
parabiosis;
bone ... See more keywords