Mice lacking PECAM-1 and Ceacam1 have an aberrant platelet and thrombus phenotype.
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DOI: 10.1055/a-1663-8108
Abstract: The immunoglobulin (Ig)-immunoreceptor tyrosine-based inhibitory motif (ITIM) bearing receptors, PECAM-1 and CEACAM1 have been shown net negative regulators of platelet-collagen interactions and hemi-ITAM signalling pathways. In this study, a double knockout (DKO) mouse was developed… read more here.
Keywords: dko platelets; ceacam1; pecam ceacam1; platelet ... See more keywords