Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide
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DOI: 10.1021/acsomega.2c05915
Abstract: This study focused on investigating diketopiperazine (DKP) and the formation of associated double-amino-acid deletion impurities during linear solid-phase peptide synthesis (SPPS) of tirzepatide (TZP). We identified that the DKP formation primarily occurred during the Fmoc-deprotection… read more here.
Keywords: dkp formation; pro ser; synthesis; solid phase ... See more keywords