Lipid-based Nanocarriers Enabled Oral Delivery of Oleanolic Acid Derivative DKS26 for Diabetes Management.
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DOI: 10.1002/adhm.202300639
Abstract: Oleanolic acid (OA, (3β)-3-hydroxy-oleanol-12-en-28-oic acid) derivative DKS26 has hypolipidemic, islet and hepatoprotective effects. However, high lipophilicity and low water solubility of DKS26 led to its extremely low oral bioavailability. Herein, lipid-based nanocarriers, including lipid nanodiscs… read more here.
Keywords: dks26; lipid based; acid derivative; based nanocarriers ... See more keywords