DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01796-2
Abstract: Axon degeneration is a prominent component of many neurological disorders. Identifying cellular pathways that contribute to axon vulnerability may identify new therapeutic strategies for maintenance of neural circuits. Dual leucine zipper kinase (DLK) is an… read more here.
Keywords: dlk; degeneration; axon survival; sarm1 dependent ... See more keywords
Diffuse lamellar keratitis after epi-off corneal crosslinking: An under-recognized complication?
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2019.01.004
Abstract: Purpose To report diffuse lamellar keratitis (DLK) occurring in an eye that underwent epithelium-off (epi-off) corneal cross-linking (CXL) as a treatment for post-surgical ectasia and the successful treatment of progressive ectasia with a novel epi-on… read more here.
Keywords: dlk; ectasia; treatment; cxl ... See more keywords
Regulation of dual leucine zipper kinase activity through its interaction with calcineurin.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109953
Abstract: Hyperglycemia enhancing the intracellular levels of reactive oxygen species (ROS) contributes to dysfunction and progressive loss of beta cells and thereby to diabetes mellitus. The oxidation sensitive calcium/calmodulin dependent phosphatase calcineurin promotes pancreatic beta cell… read more here.
Keywords: dlk; calcineurin; kinase; dual leucine ... See more keywords
In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02074
Abstract: Dual leucine zipper kinase (DLK), expressed primarily in neuronal cells, is a regulator of neuronal degeneration in response to cellular stress from chronic disease or neuronal injury. This makes it an attractive target for the… read more here.
Keywords: chemistry; kai 11101; dlk; disease neuronal ... See more keywords
Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58036-6
Abstract: Inhibiting dual leucine-zipper kinase (DLK) could potentially ameliorate diverse neuropathological conditions, but a direct inhibitor of DLK’s kinase domain caused unintended side effects in human patients, indicative of neuronal cytoskeletal disruption. We sought a more… read more here.
Keywords: dlk palmitoylation; acute axonal; palmitoylation; dlk ... See more keywords
A new therapeutic target in view
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.357.6352.656-f
Abstract: Neurodegeneration The genetics, pathology, and clinical manifestations of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) are heterogeneous, which makes the development and testing of candidate therapeutics difficult. Le Pichon et al. identified dual leucine… read more here.
Keywords: dlk; target view; target; new therapeutic ... See more keywords
Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21144849
Abstract: Dual leucine zipper kinase (DLK, Map3k12) is an axonal protein that governs the balance between degeneration and regeneration through its downstream effectors c-jun N-terminal kinase (JNK) and phosphorylated c-jun (p-c-Jun). In peripheral nerves DLK is… read more here.
Keywords: dlk; leucine zipper; jun; kinase ... See more keywords