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   Articles with "dlk1" as a keyword



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Dlk1 regulates quiescence in calcitonin receptor‐mutant muscle stem cells

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recommendations! Published in 2020 at "STEM CELLS"

DOI: 10.1002/stem.3312

Abstract: Muscle stem cells, also called muscle satellite cells (MuSCs), are responsible for skeletal muscle regeneration and are sustained in an undifferentiated and quiescent state under steady conditions. The calcitonin receptor (CalcR)‐protein kinase A (PKA)‐Yes‐associated protein… read more here.

Keywords: cko muscs; calcr cko; calcr; dlk1 ... See more keywords

Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells

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recommendations! Published in 2018 at "Angiogenesis"

DOI: 10.1007/s10456-018-9596-7

Abstract: AimDelta-like 1 homolog (DLK1) is a non-canonical ligand of Notch signaling, which plays a pivotal role in vascular development and tumor angiogenesis. This study aimed to elucidate the function and mechanism of DLK1 in angiogenesis.Methods… read more here.

Keywords: dlk1; angiogenesis; like homolog; notch1 akt ... See more keywords
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LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis

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recommendations! Published in 2022 at "Cell Cycle"

DOI: 10.1080/15384101.2022.2033415

Abstract: ABSTRACT Long non-coding RNA long intergenic non-protein coding RNA 01315 (LncRNA LINC01315) has been found to be implicated in various cancers, but its role and functions in colorectal cancer (CRC) remain to be addressed. Data… read more here.

Keywords: lncrna linc01315; dlk1; linc01315 silencing; cancer ... See more keywords
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DLK1‐directed chimeric antigen receptor T‐cell therapy for hepatocellular carcinoma

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recommendations! Published in 2022 at "Liver International"

DOI: 10.1111/liv.15411

Abstract: Delta‐like homologue 1 (DLK1), a transmembrane protein, is highly expressed in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen receptor (CAR) T cells can specifically eliminate DLK1‐positive HCC cells and serve as a therapeutic… read more here.

Keywords: directed chimeric; hepatocellular carcinoma; antigen receptor; chimeric antigen ... See more keywords
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Long term in vivo Dlk1 gene transfer protects against myocardial fibrosis-induced cardiac dysfunction

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5731106

Abstract: Introduction: Cardiac fibrosis can independently contribute to the impairment of cardiac function and development of heart failure. Early activation of pro-fibrotic genetic pathways has been suggested to occur well before adverse ventricular remodeling occurs in… read more here.

Keywords: heart failure; myocardial fibrosis; physiology; dlk1 ... See more keywords
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Association study of DLK1 in girls with idiopathic central precocious puberty

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recommendations! Published in 2020 at "Journal of Pediatric Endocrinology and Metabolism"

DOI: 10.1515/jpem-2020-0014

Abstract: Abstract Objective Mutations in the delta-like 1 homolog (DLK1) gene have recently been reported in patients with idiopathic central precocious puberty (CPP). We aimed to investigate DLK1 mutations or polymorphisms in girls with CPP. Methods… read more here.

Keywords: idiopathic central; precocious puberty; dlk1; central precocious ... See more keywords
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Low Maternal DLK1 Levels at 26 Weeks Is Associated With Small for Gestational Age at Birth

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recommendations! Published in 2022 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2022.836731

Abstract: Detecting SGA (small for gestational age) during pregnancy improves the fetal and neonatal prognosis. To date, there is no valid antenatal biomarker of SGA used in clinical practice. Maternal circulating DLK1 (delta-like non-canonical notch ligand… read more here.

Keywords: dysfunction; sga; dlk1 levels; circulating dlk1 ... See more keywords
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CpG site hypomethylation at ETS1-binding region regulates DLK1 expression in Chinese patients with Tetralogy of Fallot

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recommendations! Published in 2022 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2022.12609

Abstract: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart malformation accounting for ~10% of cases. Although the pathogenesis of TOF is complex and largely unknown, epigenetics plays a huge role, specifically DNA methylation.… read more here.

Keywords: expression; methylation; cpg site; tof ... See more keywords