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   Articles with "dlk1 dio3" as a keyword



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Two sides of the Dlk1-Dio3 story in imprinting.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.10.021

Abstract: Loss of imprinting (LOI) at the Dlk1-Dio3 locus is linked to Kagami-Ogata and Temple syndromes, and to cancer, but molecular mechanisms that prevent LOI are under-studied. In this issue of Developmental Cell, Aronson et al. demarcate… read more here.

Keywords: story imprinting; two sides; dio3 story; dlk1 dio3 ... See more keywords
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Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain

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recommendations! Published in 2021 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddab071

Abstract: Abstract The Dlk1-Dio3 imprinted domain, regulated by an intergenic differentially methylated region (IG-DMR), is important for mammalian embryonic development. Although previous studies have reported that DNA methylation of a tandem repeated array sequence in paternal… read more here.

Keywords: domain; tandem; dmr; dlk1 dio3 ... See more keywords
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Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac344

Abstract: Abstract The Dlk1-Dio3 imprinted domain is controlled by an imprinting control region (ICR) called IG-DMR that is hypomethylated on the maternal allele and hypermethylated on the paternal allele. Although several genetic mutation experiments have shown… read more here.

Keywords: imprinting control; methylation; dna methylation; dlk1 dio3 ... See more keywords

Identification of the porcine IG-DMR and abnormal imprinting of DLK1-DIO3 in cloned pigs

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.964045

Abstract: Correct reprogramming of the DLK1-DIO3 imprinted region is critical for the development of cloned animals. However, in pigs, the imprinting and regulation of the DLK1-DIO3 region has not been systematically analyzed. The objective of this… read more here.

Keywords: dlk1 dio3; abnormal imprinting; cloned pigs; region ... See more keywords
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Omics-Based Identification of Shared and Gender Disparity Routes in Hras12V-Induced Hepatocarcinogenesis: An Important Role for Dlk1-Dio3 Genomic Imprinting Region

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recommendations! Published in 2021 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2021.620594

Abstract: The phenomenon of gender disparity is very profound in hepatocellular carcinoma (HCC). Although previous research has revealed important roles of microRNA (miRNA) in HCC, there are no studies investigating the role of miRNAs in gender… read more here.

Keywords: hepatocarcinogenesis; gender disparity; dlk1 dio3; dio3 genomic ... See more keywords