Maintenance of Bone Homeostasis by DLL1‐Mediated Notch Signaling
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DOI: 10.1002/jcp.25647
Abstract: Adult bone mass is maintained through a balance of the activities of osteoblasts and osteoclasts. Although Notch signaling has been shown to maintain bone homeostasis by controlling the commitment, differentiation, and function of cells in… read more here.
Keywords: bone homeostasis; dll1; bone; physiology ... See more keywords
Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma
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DOI: 10.1136/gutjnl-2022-327076
Abstract: Objective Oesophageal adenocarcinoma (EAC) arises in the setting of Barrett’s oesophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic GERD. Here, we investigated the role of acidic bile salts, the mimicry… read more here.
Keywords: notch signaling; ape1 redox; dll1; notch ... See more keywords
Dll1-mediated Notch signaling drives tumor cell crosstalk with cancer associated fibroblasts to promote radioresistance in breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-1225
Abstract: Resistance to radiotherapy is a major obstacle for effective cancer treatment. Both cancer-associated fibroblasts (CAF) within the tumor microenvironment (TME) and Notch signaling are implicated in radioresistance, but their potential interrelationship is unclear. Here, we… read more here.
Keywords: notch signaling; breast cancer; dll1; tumor ... See more keywords
Silencing Delta-like 1 Expression Induces Migratory Features in Pancreatic Cancer Cells Through Stimulation of Src and p38 Signalling Pathway
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DOI: 10.21873/anticanres.14075
Abstract: Background/Aim: The prognosis of pancreatic cancer has not improved due to its migratory feature and refractory potential to chemo-resistance with absence of effective diagnosis. Despite continuous efforts, its underlying mechanisms of malignant nature remain ambiguous.… read more here.
Keywords: dll1; delta like; pancreatic cancer; expression ... See more keywords
Evaluation of the Novel Sepsis Biomarker Host-Derived Delta-like Canonical Notch Ligand 1—A Secondary Analysis of 405 Patients Suffering from Inflammatory or Infectious Diseases
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DOI: 10.3390/ijms24119164
Abstract: Sepsis is defined as organ failure caused by dysregulated host response to infection. While early antibiotic treatment in patients with acute infection is essential, treating non-infectious patients must be avoided. Current guidelines recommend procalcitonin (PCT)… read more here.
Keywords: sepsis; derived delta; infection; dll1 ... See more keywords