The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Ophthalmology"
DOI: 10.1155/2018/3565292
Abstract: Background Retina is the highest oxygen-demanding and vascularized tissue in the body. Retinal development and function require proper vascularization and blood vessel function and integrity. Dll4 is most prominently expressed in the endothelium of angiogenic… read more here.
Keywords: normal pathological; blood vessel; dll4 notch; vessel sprouting ... See more keywords
Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.134170
Abstract: The molecular mechanisms by which endothelial cells (ECs) regulate pulmonary vascularization and contribute to alveolar epithelial cell development during lung morphogenesis remain unknown. We tested the hypothesis that delta-like 4 (DLL4), an EC Notch ligand,… read more here.
Keywords: delta like; lung; mice; alveolarization ... See more keywords
Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth
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DOI: 10.18632/oncotarget.16969
Abstract: Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands are upregulated… read more here.
Keywords: angiogenesis; jag1; tumour growth; tumour angiogenesis ... See more keywords
Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5997
Abstract: Pituitary adenoma (PA) is a common type of benign tumor of the pituitary gland that is characterized by specific signs and symptoms, primarily associated with hypersecretion of pituitary glycoprotein hormones (thyroid-stimulating, growth and adrenocorticotrophic hormones,… read more here.
Keywords: notch1 receptor; expression notch1; receptor; dll3 ... See more keywords