Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab679
Abstract: Abstract To reconstruct systematically hyperactive transcription factor (TF)-dependent transcription networks in squamous cell carcinomas (SCCs), a computational method (ELMER) was applied to 1293 pan-SCC patient samples, and 44 hyperactive SCC TFs were identified. As a… read more here.
Keywords: dlx5 cooperates; squamous cell; bivalent; factor ... See more keywords
EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.619795
Abstract: Myelodysplastic syndrome (MDS) is characterized by clonal hematopoiesis and impaired differentiation, and may develop to acute myeloid leukemia (AML). We explored the mechanism of histone methyltransferase EZH2/EHMT2 during the transformation of MDS into AML. Expression… read more here.
Keywords: ezh2 ehmt2; skm cells; ezh2; mds ... See more keywords
DLX Genes: Roles in Development and Cancer
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DOI: 10.3390/cancers13123005
Abstract: Simple Summary DLX homeobox family genes encode transcription factors that have indispensable roles in embryonic and postnatal development. These genes are critically linked to the morphogenesis of craniofacial structures, branchial arches, forebrain, and sensory organs.… read more here.
Keywords: dlx; dlx genes; cancer; dlx5 ... See more keywords